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  1. Systemic inflammatory response syndrome (SIRS) remains a serious health problem that consumes a large amount of medical resources. The objective of the study was to investigate whether older patients with a hi...

    Authors: Jingjing Chen, Xiaorui Chen, Hanbin Xie, Ziqing Hei, Zifeng Liu and Chaojin Chen
    Citation: Lipids in Health and Disease 2025 24:82
    Content type: Research Published on:

  3. The arthritis burden increases with aging, while blood glucose, lipid profiles and inflammatory markers may affect the development of arthritis. This study aims to determine the associations between blood mark...

    Authors: Fanji Qiu, Jinfeng Li and Kirsten Legerlotz
    Citation: Lipids in Health and Disease 2025 24:79
    Content type: Research Published on:

  4. Gallstones have been linked to obesity. Relative fat mass (RFM) has emerged as a novel obesity index that more precisely represents the body fat distribution. The correlation between RFM and the risk of develo...

    Authors: Xiaochun Lin, Hao Lin, Jing Xu, Shouxing Yang and Lei Miao
    Citation: Lipids in Health and Disease 2025 24:78
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2025 24:95

  5. Various research in the past has indicated that the NHHR, which represents the ratio of non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C), and body mass index...

    Authors: Lingling Zhang, Yi Lai, Long Yan, Jiaping Fang and Kai Wang
    Citation: Lipids in Health and Disease 2025 24:77
    Content type: Research Published on:

  6. Cardiolipin (CL) is a signature phospholipid of mitochondria that maintains the integrity of mitochondrial membrane and supports proper mitochondrial function. Alterations in CL level and composition can impai...

    Authors: Pavels Dimitrijevs, Ilona Freiliba, Andrejs Pčolkins, Marcis Leja and Pavel Arsenyan
    Citation: Lipids in Health and Disease 2025 24:76
    Content type: Research Published on:

  7. Hypothyroidism is a risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD) but it is not clear whether subclinical hypothyroidism (SCH) increases the risk of MASLD and whether SCH pat...

    Authors: Sicheng Pu, Binbin Zhao, Yuxuan Jiang and Xuejiao Cui
    Citation: Lipids in Health and Disease 2025 24:75
    Content type: Review Published on:

  8. Elevated incidence of metabolic disorders has been reported worldwide in the recent decade, highlighting the need for developing efficient therapies. These diseases result from a complex interplay of various f...

    Authors: Alaa El-Kurjieh, Reem Al-Arab, Qamar Abou Hachem, José-Noel Ibrahim and Philippe Hussein Kobeissy
    Citation: Lipids in Health and Disease 2025 24:74
    Content type: Review Published on:

  9. Triglyceride glucose (TyG) index and atherogenic index of plasma (AIP) are indicators of insulin resistance. However, inadequate evidence indicates that the TyG index, AIP, and chronic pain are linked.

    Authors: Zi Yan, Hongyu Zhang, Shumei Liu, Jian Cui, Yanfei Zhu, Guoxu Zhao, Renwei Liu and Rongjun Cui
    Citation: Lipids in Health and Disease 2025 24:73
    Content type: Research Published on:

  10. Coronary heart disease (CHD) represents a severe form of ischemic cardiac condition that necessitates timely and accurate diagnosis. Although coronary angiography (CAG) remains widely used to detect CHD, healt...

    Authors: Huihui Yang, Jie Dou, Ruoling Guo, Mingliang Sun, Jie Gao, Hong-Jun Shu, Hewei Sun, Xintao Zhao, Yuhua Song, Yanchun Hou, Xiaojun Wang and Donglei Luo
    Citation: Lipids in Health and Disease 2025 24:72
    Content type: Research Published on:

  11. Dyslipidemia is a key contributor to atherosclerotic cardiovascular disease (ASCVD). Despite the well-established correlation between abnormal lipid metabolism and ASCVD, existing diagnostic and predictive mod...

    Authors: Hongli Wan, Haisheng Wu, Yuxi Wei, Simin Wang and Yuqiang Ji
    Citation: Lipids in Health and Disease 2025 24:71
    Content type: Research Published on:

  12. Bile acids are essential for energy metabolism. Deoxycholic acid (DCA) in particular is associated with metabolic disorders such as type 2 diabetes mellitus (T2DM) and obesity. However, the direct effects of D...

    Authors: Gulinigaer Tuerhongjiang, Yang Li, Zixuan Meng, Xiyu Gao, Yuanyuan Wei, Gulinigaer Muhetaer, Peiqi Li, Yi Zhang, Jiaming Zhang, Yue Wu and Junhui Liu
    Citation: Lipids in Health and Disease 2025 24:70
    Content type: Research Published on:

  13. Hepatocellular carcinoma (HCC) is the third deadliest malignant tumor worldwide. Most patients are initially diagnosed as HCC at advanced stages and are too late for radical treatment by surgery, resulting in ...

    Authors: Yuyao Yuan, Donghao Yin, Xuemeng Yang, Di Liu, Hui Shan, Juan Luo, Xiuhui Li and Yuxin Yin
    Citation: Lipids in Health and Disease 2025 24:69
    Content type: Research Published on:

  14. Trimester-specific reference intervals (TSRIs) for maternal lipid profiles should be determined, and the impact of dyslipidemia on adverse pregnancy outcomes (APOs) should be estimated.

    Authors: Lili Yang, Zhaozhen Liu, Jiayi Chen, Chong Miao, Qingxiu Li, Jinying Chen, Wenjuan Liu, Haiyan Gao, Wei Li, Zhengqin Wu, Bin Sun, Yibing Zhu and Haibo Li
    Citation: Lipids in Health and Disease 2025 24:68
    Content type: Research Published on:

  15. This study aims to evaluate the relationship between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and blood eosinophil counts (BEOC) in asthmatic patients, using data from the National Heal...

    Authors: Qian Zhao, Peng Yang, Jing-Pan Li, Lei Du, Wei Wang, Si-Xuan Zhu, Shan Wu and Yun-Feng Chen
    Citation: Lipids in Health and Disease 2025 24:67
    Content type: Research Published on:

  16. Short-chain fatty acids (SCFAs), key metabolites produced by gut microbiota, have neuroprotective effects in neurodegenerative diseases by modulating immune responses. However, their role in human immunodefici...

    Authors: Xue Chen, Jiaqi Wei, Ling Zhang, Hu Wang, Yang Zhang, Zhen Li, Xia Wang, Lifeng Liu, Yulin Zhang and Tong Zhang
    Citation: Lipids in Health and Disease 2025 24:66
    Content type: Research Published on:

  17. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors have demonstrated significant efficacy in lowering low-density lipoprotein cholesterol (LDL-C) levels in patients with atherosclerotic cardiovas...

    Authors: Xiaochun Duan, Mengdi Zhang, Xiaodong Sun, Yang Lin and Wenxing Peng
    Citation: Lipids in Health and Disease 2025 24:65
    Content type: Research Published on:

  18. Insulin resistance (IR) reduces insulin efficacy and heightens the danger of cardiovascular diseases including hypertension. The Metabolic Score for Insulin Resistance (METS-IR), which is based on triglyceride...

    Authors: Zhen Guo, Xia Guo, Hanchi Xu, Haoxuan Chu, Yulin Tian, Shipeng Wang and Yushi Wang
    Citation: Lipids in Health and Disease 2025 24:64
    Content type: Research Published on:

  19. The Inflammatory Load Index (IBI) and Body Roundness Index (BRI) were employed to evaluate the systemic inflammatory status and body fat. This study aims to elucidate the association between IBI and the preval...

    Authors: Yuting Gu, Zhanyi Zhou, Xuan Zhao, Xiaolu Ye, Keyi Qin, Jiahui Liu, Xiao Zhang and Yunxi Ji
    Citation: Lipids in Health and Disease 2025 24:63
    Content type: Research Published on:

  20. Pancreatic cancer (PC) ranks sixth globally among cancer deaths, imposing a significant burden on healthcare systems worldwide. Although diet is known to be a major risk factor, Although diet is a well-establi...

    Authors: Kexin Jiang, Zhirong Zhao, Mu Yuan, Hua Ji, Yiwen Zhao, Hanyu Ding, Jiajie Feng, Yongjiang Zhou and Ruiwu Dai
    Citation: Lipids in Health and Disease 2025 24:62
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2025 24:90

  21. Lipid metabolism is a well-regulated process essential for maintaining cellular functions and energy homeostasis. Dysregulation of lipid metabolism is associated with various conditions, including cardiovascul...

    Authors: Tikam Chand Dakal, Feng Xiao, Chandra Kanta Bhusal, Poorna Chandrika Sabapathy, Rakesh Segal, Juan Chen and Xiaodong Bai
    Citation: Lipids in Health and Disease 2025 24:61
    Content type: Review Published on:

  23. The monocyte-high-density lipoprotein cholesterol ratio (MHR) serves as an integrated indicator of the pro-inflammatory role of monocytes and anti-inflammatory properties of high-density lipoprotein cholestero...

    Authors: Qin Zhang, Jing Xia, Rongjuan Zhuang, Jun Wen and Changfen Wang
    Citation: Lipids in Health and Disease 2025 24:59
    Content type: Research Published on:

  24. Hypothyroidism, a prevalent thyroid hormone abnormality identified by biochemical indicators, is prone to serious consequences because of its insidious clinical manifestations and easy underdiagnosis. This res...

    Authors: Xinyi Huang, Hengzheng Cheng, Shuting Wang, Laifu Deng, Jiaxiu Li, An Qin, Chunqiang Chu and Xiao Liu
    Citation: Lipids in Health and Disease 2025 24:58
    Content type: Research Published on:

  25. Metabolic syndrome (MetS) is increasingly diagnosed in individuals with normal body weight, and visceral fat emerges as a significant risk factor. However, the relationship between visceral fat area (VFA) and ...

    Authors: Yongbing Sun, Xinbei Lin, Zhi Zou, Yang Zhou, Ao Liu, Xin Li, Yawei Du, Xiaoqi Ji, Zhonglin Li, Xiaoling Wu, Yong Wang, Xue Lv, Tao Li, Jiancheng Zhang, Zhiping Guo, Hao Li…
    Citation: Lipids in Health and Disease 2025 24:57
    Content type: Research Published on:

  27. Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease worldwide. Previous studies have reported that fucoidan can relieve obesity and hepatic steatosis in vivo, although the mol...

    Authors: Xueru Chu, Xuan Wang, Keqing Feng, Yanzhen Bi, Yongning Xin and Shousheng Liu
    Citation: Lipids in Health and Disease 2025 24:55
    Content type: Research Published on:

  28. The neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) is closely related to the occurrence and severeness of coronary stenosis in subjects with acute coronary syndrome (ACS). Men have higher NHR l...

    Authors: Chuntian Wang, Kun Shang, Lina Cao, Jiangying Kuang, Xiang Ning and Huiqiang Chen
    Citation: Lipids in Health and Disease 2025 24:54
    Content type: Research Published on:

  29. This study aimed to examine the relationships between remnant cholesterol (RC) and the risk of aortic aneurysm and dissection (AAD).

    Authors: Ting Zhou, Wenhui Lin, Bangyuan Yang, Yuan Liu, Wenhui Huang, Nianjin Xie, Fan Yang, Zhuoheng Lin, Ziyang Hu, Songyuan Luo and Jianfang Luo
    Citation: Lipids in Health and Disease 2025 24:53
    Content type: Research Published on:

  30. Renin plays a significant role in the regulation of blood pressure and fluid volume by modulating the renin‒angiotensin‒aldosterone (RAAS) system. Renin suppression reduces serum aldosterone levels and lowers ...

    Authors: Undurti N. Das, Ahmet Hacimüftüoglu, Erol Akpinar, Mustafa Gul and A. M. Abd El-Aty
    Citation: Lipids in Health and Disease 2025 24:52
    Content type: Hypothesis Published on:

  31. A wealth of evidence indicates that dyslipidemia is associated with endothelial dysfunction, oxidative stress, and inflammation, each of which can impair reproductive function and lead to infertility. The Athe...

    Authors: Zihong Bao, Yanmei Zhang, Ju Zhou and Zhikun Dai
    Citation: Lipids in Health and Disease 2025 24:51
    Content type: Research Published on:

    The Correction to this article has been published in Lipids in Health and Disease 2025 24:104

  32. Cardio-kidney-metabolic diseases are major causes of premature death worldwide, with type 2 diabetes mellitus (T2DM) playing a critical role. Inflammation and insulin resistance have been implicated in the pat...

    Authors: Yang Li, Xiaotong Guo, Jianli Ge, Qingqing Li, Xin Chen, Yingqian Zhu, Huixiao Yuan, Shasha Geng and Yue Liu
    Citation: Lipids in Health and Disease 2025 24:50
    Content type: Research Published on:

  33. It is well established that increased lipoprotein(a) [Lp(a)] is a significant risk factor for coronary artery disease (CAD). Plasma Lp(a) levels are genetically determined and vary widely between different rac...

    Authors: Jie Li, Ben Ma, Qin Fang, Jing Wang, Yang Sun, Hu Ding and Yan Wang
    Citation: Lipids in Health and Disease 2025 24:49
    Content type: Research Published on:

  34. Explore the relationship between the triglyceride-glucose (TyG) index, along with its derivative indices, and the prevalence of cataracts.

    Authors: Bin Wei, Xin Hu, Ben-Liang Shu, Qin-Yi Huang, Hua Chai, Hao-Yu Yuan, Lin Zhou, Yi-Chong Duan, Li-Li Yao, Zhuo-Er Dong and Xiao-rong Wu
    Citation: Lipids in Health and Disease 2025 24:48
    Content type: Research Published on:

  35. Soluble lectin-like oxidised low-density lipoprotein receptor 1 (sLOX-1) is overproduced during inflammation, with its expression and release triggered by C-reactive protein (CRP). As CRP levels are typically ...

    Authors: Patricia Mester, Charlotte Birner, Stephan Schmid, Martina Müller, Vlad Pavel and Christa Buechler
    Citation: Lipids in Health and Disease 2025 24:47
    Content type: Research Published on:

  36. In cardiovascular diseases (CVD) and insulin resistance (IR), elevated blood lipids and glucose are common. These abnormalities accelerate atherosclerosis and may impair insulin signaling via oxidative stress ...

    Authors: Yitao Hu, Yuzhe Kong, Xinling Tian, Xinyi Zhang and Yu Zuo
    Citation: Lipids in Health and Disease 2025 24:46
    Content type: Research Published on:

  37. The prevalence of prediabetes among adults in the U.S. is three times higher than that of diabetes, highlighting a greater disease burden. Both diabetes and prediabetes have been demonstrated to be associated ...

    Authors: Erya Xiao, Ronghui Yu, Xinyuan Cai, Lang Jiang, Junhong Li, Cong Ma, Yuankang Liu, Le Liu, Guanghao Su and Xiaodong Wang
    Citation: Lipids in Health and Disease 2025 24:45
    Content type: Research Published on:

  38. The impact of a high-salt (HS) diet on metabolic disturbances in individuals with coronary heart disease remains unclear. The arachidonic acid (AA) metabolic pathway is closely linked to the development of car...

    Authors: Zhuoran Jia, Jian Wu, Fang Liu, Huimin Wang, Peiyang Zheng, Bing Shen and Ren Zhao
    Citation: Lipids in Health and Disease 2025 24:44
    Content type: Research Published on:

  39. Maternal glucose and lipid levels are known to influence fetal growth. However, data on how maternal lipid profiles affect birth size in women with gestational diabetes (GDM) compared with those without GDM ar...

    Authors: Jing Peng, Li Zhang, Jing Jin, Huazhang Miao, Guocheng Liu and Yong Guo
    Citation: Lipids in Health and Disease 2025 24:43
    Content type: Research Published on:

  40. In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density ...

    Authors: Zhiwei Xue, Jian Cao, Jianhui Mou, Rui Wang and Peng Liu
    Citation: Lipids in Health and Disease 2025 24:42
    Content type: Research Published on:

  41. The liver‒brain axis is critical in neurodegenerative diseases (NDs), with lipid metabolism influencing neuroinflammation and microglial function. A systematic investigation of the genetic relationship between...

    Authors: Zeyu Wang, Zixiao Yin, Guangyong Sun, Dong Zhang and Jianguo Zhang
    Citation: Lipids in Health and Disease 2025 24:41
    Content type: Research Published on:

  42. Free fatty acids (FFA) can increase the expression of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in local tissues and organs. However, the mechanism underlying the effect of FFA on 11β-HSD1 expression remai...

    Authors: Dandan Liu, Peipei Tian, Yilin Hou, Tingxue Zhang, Xiaoyu Hou, Lifang Liu, Xiaolong Li, Kunjie Zheng, Chao Wang and Guangyao Song
    Citation: Lipids in Health and Disease 2025 24:40
    Content type: Research Published on:

  43. The development of metastasis is a leading cause of cancer-related death that involves specific changes in the plasma membrane (PM) and nucleus of cancer cells. Elevated levels of membrane lipids, including sp...

    Authors: Agnieszka Chytła, Stephanie Rattay, Baki Akgül and Martin Sztacho
    Citation: Lipids in Health and Disease 2025 24:39
    Content type: Review Published on:

  44. This study aimed to analyse the relationship of the blood lipid profile and interleukin-6 (IL-6) with osteoporosis and osteopenia and to explore the predictive value of the combined application of these biomar...

    Authors: Liping Fan, Jiahao Chen, Chong Chen, Yongwei Zhang, Yeqing Yang and Zhe Chen
    Citation: Lipids in Health and Disease 2025 24:38
    Content type: Research Published on:

  45. The impact of a healthy diet on the secondary prevention of ischemic stroke (IS) remains uncertain. Levels of low-density lipoprotein cholesterol (LDL-C) are inversely associated with the risk of IS recurrence...

    Authors: Verónica V. Olavarría, Paola R. Campodónico, Valeska Vollrath, Paula von Geldern, Carolina Velásquez, Patricia Pavez, Barbara Valente, Pamela Donoso, Alexandra Ginesta, Gabriel Cavada, Enrico Mazzon, Víctor Navia, Matías Guzmán, Pablo Brinck, Andrés Gallardo, Pablo Gonzalez…
    Citation: Lipids in Health and Disease 2025 24:37
    Content type: Research Published on:

  46. The relationship between lipid profiles and intracranial hemorrhage (ICH) has garnered increasing attention. The ratio of low-density lipoprotein to high-density lipoprotein (LHR) is one of the key lipid profi...

    Authors: Yuchen Liu, Houxin Fu, Yue Wang, Yi Zhong, Rongting Zhang, Jingxuan Sun, Tianquan Yang, Yong Han, Yongjun Xiang, Bin Yuan, Ruxuan Zhou, Min Chen and Hangzhou Wang
    Citation: Lipids in Health and Disease 2025 24:36
    Content type: Research Published on:

  47. To investigate the prognostic value of circulating apolipoprotein AI (apoAI) levels and develop a new prognostic model in individuals with acute-on-chronic liver failure (ACLF) and acute decompensation (AD) of...

    Authors: Ruidong Mo, Zhenglan Zhang, Yanmei Zhou, Yue Wang, Pengbo Yin, Chenxi Zhang, Haoshuang Fu, Cong Qian, Xiaogang Xiang, Rongkun Yin and Qing Xie
    Citation: Lipids in Health and Disease 2025 24:35
    Content type: Research Published on:

  49. The study aimed to explore potential links between long-term digestive issues (specifically diarrhea and constipation) and body roundness index (BRI) in a representative U.S. population sample.

    Authors: Yinda Wang, Fei Chen, Binzhong Zhang and Zhengwei Song
    Citation: Lipids in Health and Disease 2025 24:33
    Content type: Research Published on:

  50. SARS-CoV-2 infection affects both lipid metabolism and lung function. The severity of the disease has been associated with reduced levels of both high-density lipoprotein (HDL) and low-density lipoprotein chol...

    Authors: Floran Begue, Bryan Veeren, Philippe Rondeau, Aline-Marie Florence, Simon Jamard, Philippe Montravers, Sébastien Tanaka and Olivier Meilhac
    Citation: Lipids in Health and Disease 2025 24:32
    Content type: Research Published on:
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Lipids in Health and Disease

ISSN: 1476-511X