Fig. 3

The correlation between LDL-C related gut microbiota and tumor immune infiltrating cells. A Bar chart of relative abundance of immune cells in CRC patients grouped by LDL-C status. Each bar represents a sample, and the vertical coordinates represent the predicted relative abundance values of immune cells. The sum of the relative abundances of all immune cells in a single sample is 1, and each color in the graph corresponds to one type of immune cell. B Heat map of the correlation between dominant microbial communities and immune cell abundance in the H-LDL-C group. C Heat map of the correlation between dominant microbial communities and immune cell abundance in the L-LDL-C group. The horizontal axis represents immune cells, and the vertical axis represents microbiota. In the figure, red represents positive correlation, blue represents negative correlation, color depth represents the magnitude of Pearson correlation coefficient, and color from light to dark represents the value of Pearson correlation coefficient from small to large. The “*” in the figure represents the size of the P-value: none * represents a P-value ≥ 0.05, * represents 0.01 ≤ P < 0.05, * * represents 0.001 ≤ P < 0.01, and * * * represents P < 0.001. D Network diagram showing the correlation between LDL-C related differential gut microbiota and immune cells. Each node represents each gut microbiota or immune cell and the connecting line represents a significant correlation between the two nodes; the blue line indicates that the Pearson correlation coefficient is less than 0 (negative correlation), while the red line indicates that the Pearson correlation coefficient is greater than 0 (positive correlation)