Fig. 5
From: Resveratrol improved atherosclerosis by increasing LDLR levels via the EGFR-ERK1/2 signaling pathway
RSV enhanced LDLR expression by activating EGFR-ERK signaling pathway in high-fat diet-fed ApoE-/- mice. (A) The mRNA expression of LDLR in livers was measured by RT-qPCR. (B) Western blot was performed to measure protein levels of LDLR, P-EGFR, EGFR, P-ERK and ERK in lives. (C) Immunohistochemical staining was used to analyze LDLR, P-EGFR and EGFR expression in livers. Date are expressed as mean ± SEM. Significant differences versus the control group are denoted by *P < 0.05, **P < 0.01 and ***P < 0.001 (n = 6)