Fig. 2
From: Resveratrol improved atherosclerosis by increasing LDLR levels via the EGFR-ERK1/2 signaling pathway
RSV activated EGFR-ERK1/2 signaling pathway to promote LDLR expression. (A) HepG2 cells were exploed to RSV (10 µM, 20 µM and 30 µM). Expression levels of P-EGFR, EGFR, ERK and P-ERK were analyzed by western blot. (B) Cetuximab (5 µg/ml) and RSV (20 µM) were co-administered to HepG2 cells. Protein levels of P-EGFR, EGFR, ERK, and P-ERK were assessed using western blot analysis. (C) Dil-LDL uptake was visualized under a fluorescence microscope. Date are expressed as mean ± SEM. Significant differences versus the control group are denoted by *P < 0.05, **P < 0.01, ***P < 0.001