Fig. 1
From: Resveratrol improved atherosclerosis by increasing LDLR levels via the EGFR-ERK1/2 signaling pathway
RSV elevated DiI-LDL uptake by increasing LDLR expression. (A) After treated HepG2 cells with RSV (10, 20 and 30 µM), cell viability was measured by MTT assay. (B, C) Western blot and RT-PCR were performed to assess LDLR protein and mRNA levels, respectively. (D) DiI-LDL uptake was detected under a fluorescence microscope. (E) HepG2 cells were exposed to actinomycin D and RSV (20 µM), followed by RT-qPCR analysis to assess LDLR mRNA level. Date are expressed as mean ± SEM. Significant differences versus the control group are denoted by **P < 0.01 and ***P < 0.001