Metabolic Biomarkers | BRI trajectory | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
All patients (n = 669) |  | Subgroup analysis of participants with abnormalities at T0 # | ||||||||
Low-gradual decline (n = 539) | High-rapid decline (n = 76) | High-gradual decline (n = 54) |  | High-rapid decline | High-gradual decline | |||||
OR(95%CI) | OR(95%CI) | P | OR(95%CI) | P | Â | OR(95%CI) | P | OR(95%CI) | P | |
Model 0 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TG | 1.00 (Ref) | 1.93 (0.99 ~ 3.75) | 0.051 | 3.28 (1.67 ~ 6.42) | 0.001* |  | 1.11 (0.43 ~ 2.85) | 0.828 | 4.24 (1.77 ~ 10.18) | 0.001* |
HDL-C | 1.00 (Ref) | 2.84 (1.73 ~ 4.67) | < 0.001* | 4.30 (2.31 ~ 8.00) | < 0.001* |  | 2.61 (1.42 ~ 4.82) | 0.002* | 4.11 (1.90 ~ 8.90) | < 0.001* |
LDL-C | 1.00 (Ref) | 1.03 (0.54 ~ 1.95) | 0.929 | 2.10 (1.12 ~ 3.93) | 0.020* |  | 1.53 (0.69 ~ 3.38) | 0.297 | 3.39 (1.34 ~ 8.61) | 0.010* |
GLU | 1.00 (Ref) | 1.63 (0.99 ~ 2.67) | 0.052 | 1.09 (0.60 ~ 1.99) | 0.783 |  | 2.24 (0.98 ~ 5.10) | 0.055 | 1.05 (0.43 ~ 2.57) | 0.909 |
UA | 1.00 (Ref) | 1.54 (0.95 ~ 2.51) | 0.081 | 2.33 (1.33 ~ 4.10) | 0.003* |  | 1.33 (0.77 ~ 2.28) | 0.311 | 1.88 (0.94 ~ 3.77) | 0.073 |
Model 1 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TG | 1.00 (Ref) | 1.66 (0.84 ~ 3.29) | 0.145 | 3.40 (1.68 ~ 6.85) | 0.001* |  | 1.05 (0.39 ~ 2.81) | 0.909 | 4.47 (1.76 ~ 11.32) | 0.002* |
HDL-C | 1.00 (Ref) | 2.90 (1.74 ~ 4.85) | < 0.001* | 4.40 (2.33 ~ 8.33) | < 0.001* |  | 2.51 (1.34 ~ 4.70) | 0.004* | 4.40 (1.98 ~ 9.74) | < 0.001* |
LDL-C | 1.00 (Ref) | 1.04 (0.54 ~ 2.02) | 0.885 | 2.03 (1.06 ~ 3.87) | 0.031* |  | 1.62 (0.7 ~ 3.76) | 0.258 | 3.90 (1.46 ~ 10.40) | 0.006* |
GLU | 1.00 (Ref) | 1.38 (0.82 ~ 2.33) | 0.223 | 0.89 (0.47 ~ 1.67) | 0.892 |  | 2.34 (0.88 ~ 6.19) | 0.086 | 0.85 (0.31 ~ 2.30) | 0.753 |
UA | 1.00 (Ref) | 1.38 (0.83 ~ 2.28) | 0.209 | 2.61 (1.45 ~ 4.67) | 0.001* |  | 1.19 (0.67 ~ 2.08) | 0.543 | 2.05 (0.99 ~ 4.18) | 0.051 |
Model 2 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TG | 1.00 (Ref) | 1.69 (0.86 ~ 3.33) | 0.128 | 2.63 (1.29 ~ 5.34) | 0.008* |  | 1.01 (0.39 ~ 2.66) | 0.969 | 3.54 (1.38 ~ 9.10) | 0.009* |
HDL-C | 1.00 (Ref) | 2.67 (1.61 ~ 4.43) | < 0.001* | 3.79 (2.01 ~ 7.16) | < 0.001* |  | 2.50 (1.35 ~ 4.63) | 0.004* | 3.65 (1.66 ~ 8.05) | 0.001* |
LDL-C | 1.00 (Ref) | 0.87 (0.45 ~ 1.68) | 0.678 | 1.57 (0.81 ~ 3.06) | 0.179 |  | 1.28 (0.55 ~ 2.94) | 0.559 | 2.57 (0.96 ~ 6.85) | 0.058 |
GLU | 1.00 (Ref) | 1.62 (0.98 ~ 2.67) | 0.058 | 1.07 (0.57 ~ 1.99) | 0.820 |  | 2.26 (0.98 ~ 5.19) | 0.054 | 1.13 (0.45 ~ 2.83) | 0.795 |
UA | 1.00 (Ref) | 1.50 (0.91 ~ 2.47) | 0.106 | 2.17 (1.21 ~ 3.88) | 0.009* |  | 1.27 (0.73 ~ 2.21) | 0.396 | 1.67 (0.82 ~ 3.44) | 0.157 |
Model 3 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TG | 1.00 (Ref) | 1.86 (0.92 ~ 3.76) | 0.083 | 3.23 (1.64 ~ 6.38) | 0.001* |  | 1.10 (0.41 ~ 2.93) | 0.838 | 4.00 (1.63 ~ 9.78) | 0.002* |
HDL-C | 1.00 (Ref) | 2.56 (1.52 ~ 4.32) | < 0.001* | 4.18 (2.23 ~ 7.81) | < 0.001* |  | 2.39 (1.24 ~ 4.60) | 0.009* | 4.09 (1.88 ~ 8.91) | < 0.001* |
LDL-C | 1.00 (Ref) | 1.11 (0.56 ~ 2.18) | 0.746 | 2.18 (1.15 ~ 4.12) | 0.016* |  | 1.53 (0.64 ~ 3.66) | 0.330 | 3.47 (1.34 ~ 8.98) | 0.010* |
GLU | 1.00 (Ref) | 1.58 (0.92 ~ 2.73) | 0.098 | 1.11 (0.60 ~ 2.04) | 0.724 |  | 2.36 (0.98 ~ 5.63) | 0.053 | 1.02 (0.41 ~ 2.54) | 0.950 |
UA | 1.00 (Ref) | 1.64 (0.98 ~ 2.75) | 0.057 | 2.39 (1.35 ~ 4.22) | 0.003* |  | 1.37 (0.77 ~ 2.46) | 0.279 | 1.93 (0.96 ~ 3.89) | 0.065 |
Model 4 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
TG | 1.00 (Ref) | 1.35 (0.64 ~ 2.83) | 0.427 | 2.66 (1.26 ~ 5.63) | 0.010* |  | 0.91 (0.32 ~ 2.53) | 0.857 | 3.33 (1.21 ~ 9.19) | 0.020* |
HDL-C | 1.00 (Ref) | 2.35 (1.36 ~ 4.06) | 0.002* | 3.63 (1.88 ~ 7.01) | < 0.001* |  | 2.11 (1.07 ~ 4.16) | 0.030* | 3.83 (1.68 ~ 8.70) | 0.001* |
LDL-C | 1.00 (Ref) | 0.83 (0.40 ~ 1.71) | 0.628 | 1.52 (0.76 ~ 3.06) | 0.233 |  | 1.16 (0.44 ~ 3.05) | 0.755 | 2.99 (1.06 ~ 8.41) | 0.037* |
GLU | 1.00 (Ref) | 1.47 (0.83 ~ 2.58) | 0.181 | 0.92 (0.47 ~ 1.78) | 0.811 |  | 2.27 (0.79 ~ 6.52) | 0.127 | 0.88 (0.30 ~ 2.56) | 0.814 |
UA | 1.00 (Ref) | 1.43 (0.83 ~ 2.46) | 0.191 | 2.52 (1.37 ~ 4.62) | 0.003* |  | 1.14 (0.61 ~ 2.11) | 0.678 | 1.89 (0.89 ~ 4.00) | 0.096 |