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Table 1 Characteristics of the participants

From: Age-specific associations between per- and polyfluoroalkyl substances exposure and metabolic syndrome: a cross-sectional study

Characters

Adolescents (n=1171)

P value

Young adults (n=1464)

P value

The middle-aged (n=1554)

P value

The elderly (n=1661)

P value

Non-MetS (n=1082)

MetS (n=89)

Non-MetS (n=1133)

MetS (n=331)

Non-MetS (n=865)

MetS (n=689)

Non-MetS (n=713)

MetS (n=948)

Age, years

15.0 (13.0-17.0)

15.0 (13.0-17.0)

0.844

29.0 (24.0-34.0)

32.0 (27.0-35.0)

<0.001

48.0 (44.0-54.0)

50.0 (45.0-55.0)

0.001

69.0 (64.0-76.0)

69.0 (64.0-74.0)

0.505

Gender, n (%)

  

0.444

  

0.028

  

0.950

  

0.487

   Male

579 (50.6%)

53 (56.7%)

 

588 (51.7%)

187 (60.7%)

 

438 (51.3%)

335 (51.5%)

 

393 (48.7%)

444 (46.2%)

 

   Female

503 (49.4%)

36 (43.3%)

 

545 (48.3%)

144 (39.3%)

 

427 (48.7%)

354 (48.5%)

 

320 (51.3%)

504 (53.8%)

 

Race, n (%)

  

0.790

  

0.032

  

0.650

  

0.683

   Non-Hispanic White

293 (57.4%)

28 (58.3%)

 

468 (62.8%)

149 (61.6%)

 

381 (73.3%)

312 (71.8%)

 

390 (81.6%)

509 (80.1%)

 

   Non-Hispanic Black

329 (15.6%)

17 (13.8%)

 

255 (12.1%)

65 (11.7%)

 

186 (10.0%)

148 (10.8%)

 

140 (7.4%)

169 (7.8%)

 

   Mexican American

292 (14.4%)

33 (17.8%)

 

171 (9.9%)

72 (15.5%)

 

133 (6.2%)

114 (7.6%)

 

77 (3.0%)

141 (3.9%)

 

   Other

168 (12.6%)

11 (10.1%)

 

239 (15.2%)

45 (11.2%)

 

165 (10.4%)

115 (9.8%)

 

106 (8.0%)

129 (8.2%)

 

Education, n (%)

  

0.729

  

<0.001

  

<0.001

  

0.001

   Less than high school

943 (86.9%)

79 (88.8%)

 

194 (13.3%)

93 (21.4%)

 

170 (12.0%)

158 (14.4%)

 

182 (13.9%)

310 (22.0%)

 

   High school graduate and some college

139 (13.1%)

10 (11.2%)

 

655 (57.0%)

198 (62.7%)

 

424 (51.0%)

400 (61.3%)

 

365 (53.1%)

480 (55.4%)

 

   College graduate or above

   

284 (29.7%)

40 (15.9%)

 

271 (37.0%)

131 (24.4%)

 

166 (33.1%)

158 (22.7%)

 

Poverty income ratio

2.2 (1.1-4.1)

2.0 (1.1-3.4)

0.193

2.7 (1.4-4.3)

2.1 (1.0-3.3)

<0.001

4.0 (2.0-5.0)

3.1 (1.6-5.0)

<0.001

3.4 (1.9-5.0)

3.0 (1.5-4.7)

<0.001

Smoker, n (%)

305 (26.9%)

26 (25.6%)

0.820

399 (37.3%)

143 (43.5%)

0.085

407 (47.5%)

355 (52.2%)

0.158

361 (48.9%)

506 (54.6%)

0.120

Drinker, n (%)

61 (6.1%)

4 (3.5%)

0.481

905 (83.6%)

253 (80.2%)

0.234

681 (85.5%)

517 (78.9%)

0.004

502 (75.8%)

647 (71.0%)

0.146

BMI, kg/m2

22.3 (19.5-26.2)

32.9 (29.8-38.8)

<0.001

25.3 (22.5-29.0)

33.1 (29.2-38.8)

<0.001

26.3 (23.2-29.1)

31.7 (28.0-37.0)

<0.001

25.2 (22.5-28.2)

30.5 (27.5-34.0)

<0.001

Energy, kcal/d

1940.3 (1392.7-2617.7)

1977.3 (1294.6-3035.8)

0.695

2190.6 (1610.0-3000.1)

2368.1 (1603.9-3045.9)

0.236

2120.2 (1605.7-2703.0)

2161.9 (1570.2-2732.0)

0.879

1882.4 (1388.0-2425.1)

1780.0 (1350.5-2227.0)

0.070

MetS components

Waist circumference, cm

77.6 (71.0-89.0)

109.1 (98.8-120.4)

<0.001

88.1 (80.7-98.0)

108.6 (99.5-123.1)

<0.001

93.1 (84.3-100.8)

107.5 (99.6-118.2)

<0.001

92.9 (85.0-101.5)

107.5 (100.6-116.4)

<0.001

Systolic, mmHg

108.0 (102.0-116.0)

120.0 (110.1-122.7)

<0.001

112.0 (106.0-120.0)

122.0 (114.0-132.0)

<0.001

116.0 (108.0-124.0)

126.0 (116.0-136.0)

<0.001

126.0 (114.0-140.0)

132.7 (122.0-144.0)

<0.001

Diastolic, mmHg

60.0 (54.0-68.0)

66.0 (56.0-74.0)

0.009

66.0 (60.0-74.0)

74.0 (68.0-84.0)

<0.001

72.0 (66.0-78.0)

76.0 (70.0-84.0)

<0.001

68.0 (60.0-74.0)

68.0 (60.0-76.0)

0.673

Serum triglyceride, mg/dL

69.0 (51.0-94.0)

143.6 (122.0-177.0)

<0.001

79.0 (57.0-110.2)

161.4 (105.8-226.0)

<0.001

92.0 (65.0-122.0)

167.0 (115.0-228.1)

<0.001

89.0 (64.0-120.0)

149.0 (105.6-192.0)

<0.001

Serum HDL-cholesterol, mg/dL

52.0 (45.0-61.0)

38.0 (33.7-40.0)

<0.001

54.0 (47.0-64.0)

39.0 (35.0-45.0)

<0.001

56.0 (48.0-71.0)

43.0 (38.0-50.0)

<0.001

64.0 (52.0-75.0)

47.0 (40.2-57.0)

<0.001

Serum fasting glucose, mg/dL

94.0 (89.0-98.0)

100.9 (95.9-105.0)

<0.001

93.5 (88.0-99.0)

102.0 (99.0-110.0)

<0.001

96.0 (91.0-103.0)

106.4 (101.0-117.0)

<0.001

98.0 (93.0-106.0)

113.0 (103.0-128.4)

<0.001

Other metabolic traits

Serum fasting insulin, μU/mL

10.0 (7.1-15.1)

25.7 (17.7-40.5)

<0.001

7.1 (4.7-11.4)

16.5 (11.0-24.6)

<0.001

6.6 (4.6-10.0)

14.0 (9.3-20.4)

<0.001

6.5 (4.6-10.6)

12.5 (8.3-19.8)

<0.001

HOMA-IR

2.3 (1.6-3.6)

6.2 (4.7-10.3)

<0.001

1.7 (1.1-2.7)

4.2 (2.8-6.7)

<0.001

1.6 (1.1-2.5)

3.8 (2.5-6.2)

<0.001

1.6 (1.1-2.6)

3.6 (2.3-5.9)

<0.001

Two-hour glucose (OGTT), mg/dL

95.0 (84.0-110.0)

113.0 (84.5-127.6)

0.004

91.0 (78.0-110.4)

110.0 (94.4-131.9)

<0.001

99.0 (82.0-118.0)

128.0 (102.0-155.0)

<0.001

110.0 (92.0-138.0)

146.0 (113.0-183.0)

<0.001

Glycohemoglobin, %

5.2 (5.0-5.4)

5.3 (5.1-5.6)

0.055

5.2 (5.0-5.4)

5.4 (5.1-5.6)

<0.001

5.4 (5.2-5.6)

5.6 (5.4-6.0)

<0.001

5.5 (5.3-5.8)

5.9 (5.5-6.4)

<0.001

Serum total cholesterol, mg/dL

153.7 (134.0-173.0)

164.7 (138.9-182.0)

0.026

174.0 (154.0-198.7)

189.0 (167.0-212.0)

<0.001

202.0 (178.0-226.0)

204.0 (178.0-236.3)

0.168

198.0 (174.0-224.0)

184.0 (158.0-217.0)

<0.001

Serum LDL-cholesterol, mg/dL

85.0 (69.0-101.0)

97.3 (74.4-114.5)

0.008

100.0 (83.0-122.1)

114.0 (95.0-136.3)

<0.001

122.0 (100.0-144.0)

124.0 (100.0-149.0)

0.375

112.2 (88.0-137.0)

104.0 (80.0-131.0)

0.004

Non-HDL-cholesterol, mg/dL

100.0 (81.0-118.0)

127.7 (105.0-145.0)

<0.001

117.0 (96.0-143.0)

151.6 (126.3-178.0)

<0.001

140.0 (119.0-169.0)

159.0 (133.0-192.3)

<0.001

133.0 (107.0-156.3)

132.0 (109.0-166.0)

0.239

  1. Notes: BMI, body mass index; HDL-C, high-density lipoprotein cholesterol; HMOA-IR, homeostasis model assessment of insulin resistance score; OGTT, oral glucose tolerance test; HbA1c, glycohemoglobin; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; NHC, non-HDL cholesterol; TG, triglyceride