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Table 3 Cox regression models for the association between lnRCII and mortality outcomes

From: Remnant cholesterol inflammatory index and its association with all-cause and cause-specific mortality in middle-aged and elderly populations: evidence from US and Chinese national population surveys

lnRCII

Person-years

No. of deaths

Model 1

Model 2

Model 3

HR (95% CI)

P

HR (95% CI)

P

HR (95% CI)

P

All-cause mortality (NHANES)

 Q1

27,345

502

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

 Q2

28,154

641

1.36 (1.13—1.64)

0.001

1.09 (0.91—1.31)

0.355

1.13 (0.94—1.35)

0.186

 Q3

29,571

722

1.61 (1.38—1.88)

 < 0.001

1.22 (1.05—1.43)

0.011

1.28 (1.08—1.51)

0.004

 Q4

28,271

833

1.90 (1.62—2.22)

 < 0.001

1.67 (1.44—1.94)

 < 0.001

1.76 (1.50—2.08)

 < 0.001

 P for trend

   

 < 0.001

 

 < 0.001

 

 < 0.001

 Per SD increase

  

1.30 (1.23—1.37)

 < 0.001

1.26 (1.19—1.33)

 < 0.001

1.29 (1.21—1.36)

 < 0.001

All-cause mortality (CHARLS)

 Q1

27,965

115

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

 Q2

27,318

123

1.11 (0.86—1.43)

0.412

1.06 (0.82—1.37)

0.637

1.03 (0.77—1.36)

0.852

 Q3

26,672

166

1.55 (1.22—1.97)

 < 0.001

1.46 (1.15—1.86)

0.002

1.36 (1.05—1.77)

0.022

 Q4

26,413

205

1.93 (1.54—2.43)

 < 0.001

1.68 (1.34—2.12)

 < 0.001

1.58 (1.22—2.04)

 < 0.001

 P for trend

   

 < 0.001

 

 < 0.001

 

 < 0.001

 Per SD increase

  

1.36 (1.25—1.47)

 < 0.001

1.28 (1.18—1.38)

 < 0.001

1.26 (1.15—1.38)

 < 0.001

CVD mortality (NHANES)

 Q1

27,345

165

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

 Q2

28,154

219

1.53 (1.13—2.07)

0.006

1.18 (0.87—1.60)

0.278

1.13 (0.82—1.55)

0.455

 Q3

29,571

216

1.64 (1.28—2.12)

 < 0.001

1.20 (0.94—1.54)

0.135

1.09 (0.84—1.41)

0.52

 Q4

28,271

260

1.91 (1.51—2.42)

 < 0.001

1.67 (1.32—2.11)

 < 0.001

1.45 (1.11—1.89)

0.007

 P for trend

   

 < 0.001

 

 < 0.001

 

0.015

 Per SD increase

  

1.29 (1.19—1.40)

 < 0.001

1.27 (1.15—1.41)

 < 0.001

1.21 (1.08—1.35)

 < 0.001

Cancer mortality (NHANES)

 Q1

27,345

108

1.00 (Reference)

 

1.00 (Reference)

 

1.00 (Reference)

 

 Q2

28,154

150

1.31 (0.87—1.99)

0.202

1.18 (0.76—1.84)

0.453

1.20 (0.75—1.90)

0.448

 Q3

29,571

166

1.42 (1.05—1.92)

0.025

1.17 (0.81—1.68)

0.397

1.28 (0.87—1.88)

0.213

 Q4

28,271

189

1.70 (1.19—2.44)

0.004

1.70 (1.10—2.64)

0.017

1.98 (1.28—3.08)

0.002

 P for trend

   

0.005

 

0.034

 

0.005

Per SD increase

  

1.22 (1.07—1.40)

0.003

1.22 (1.02—1.46)

0.029

1.30 (1.09—1.55)

0.003

  1. HRs with 95% CIs were calculated to evaluate the association between lnRCII and mortality or cause-specific mortality in the NHANES and CHALRS cohorts. The analysis was conducted using both quartile-based categorization and per SD increase models, where participants were grouped into lnRCII quartiles with the first quartile serving as the reference, and HRs were also calculated for each SD increase in lnRCII to evaluate continuous risk associations
  2. Model 1: Unadjusted
  3. Model 2: Adjusted for age, sex, race (NHANES), education level, marital status, drinking, smoking
  4. Model 3: Adjusted for age, sex, race (NHANES), education level, marital status, drinking, smoking, hypertension, diabetes, dyslipidemia, BMI,
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Lipids in Health and Disease

ISSN: 1476-511X