Longitudinal changes and patterns in cardiometabolic index and the natural course of prediabetes in the China health and retirement longitudinal study

Table 3 Cox regression analysis of the association between CMI, CMI transition patterns, CumCMI and the natural course of prediabetes

	No. of case	HR (95%CI)
	No. of case	Non-adjusted model	Model I	Model II	Model III
Prediabetes to Diabetes
CMI		1.14 (1.05, 1.24)	1.14 (1.05, 1.25)	1.13 (1.02, 1.24)	1.15 (1.03, 1.28)
CMI transition patterns
Low-to-high	74 (16.55%)	1.0	1.0	1.0
Consistently-low	82 (9.94%)	0.60 (0.44, 0.82)	0.60 (0.43, 0.82)	0.61 (0.45, 0.84)	0.63 (0.46, 0.86)
High-to-low	32 (11.72%)	0.71 (0.47, 1.07)	0.72 (0.48, 1.10)	0.72 (0.47, 1.09)	0.70 (0.46, 1.06)
Consistently-high	203 (20.32%)	1.23 (0.94, 1.60)	1.22 (0.94, 1.60)	1.15 (0.87, 1.50)	1.11 (0.83, 1.48)
CumCMI		2.24 (1.62, 3.09)	2.28 (1.64, 3.17)	2.08 (1.47, 2.95)	2.27 (1.51, 3.41)
Prediabetes to normoglycaemia
CMI		0.98 (0.89, 1.08)	0.97 (0.88, 1.07)	0.99 (0.89, 1.09)	0.93 (0.84, 1.04)
CMI transition patterns
Low-to-high	100 (22.37%)	1.0	1.0	1.0
Consistently-low	206 (24.97%)	1.12 (0.88, 1.42)	1.11 (0.87, 1.41)	1.12 (0.88, 1.44)	1.19 (0.92, 1.52)
High-to-low	65 (23.81%)	1.06 (0.78, 1.45)	1.04 (0.76, 1.42)	1.07 (0.78, 1.47)	1.21 (0.87, 1.67)
Consistently-high	204 (20.42%)	0.91 (0.72, 1.16)	0.90 (0.71, 1.14)	0.92 (0.72, 1.18)	0.97 (0.74, 1.26)
CumCMI		0.80 (0.54, 1.18)	0.78 (0.52, 1.15)	0.82 (0.55, 1.22)	0.70 (0.46, 1.06)

Abbreviations: HR hazard ratios, CI confidence interval, CMI cardiometabolic index, CumCMI cumulative CMI
Model I adjust for age, gender, smoking status, drinking status
Model II adjust for age, gender, education, CVD, stroke, hypertension, smoking status, drinking status
Model III adjust for age, gender, education, CVD, stroke, hypertension, smoking status, drinking status, height, SBP, DBP, LDL-C, HbA1c, UA, Cr

ISSN: 1476-511X