Table 1 Causality from plasma lipid on kidney stones via supplementary and sensitivity analysis. Abbreviations: CI, confidence interval; ME, MR-Egger; N: number of single nucleotide polymorphisms; OR: odds ratio; WMn: Weighted median; WM: Weighted mode
Plasma Lipid | N | MR analysis | Pleiotropy | Heterogeneity | ||||
|---|---|---|---|---|---|---|---|---|
Methods | OR(95% CI) | p | Intercept | p | Q | p | ||
Phosphatidylcholine (16:1_18:0) levels | 18 | ME | 1.100(0.955–1.267) | 0.205 | 0.006 | 0.573 | 13.389 | 0.710 |
|  |  | WMn | 1.133(1.014–1.267) | 0.028 |  |  |  |  |
|  |  | WM | 1.134(1.019–1.261) | 0.034 |  |  |  |  |
Phosphatidylcholine (18:0_20:4) levels | 25 | ME | 0.935(0.891–0.982) | 0.013 | -0.002 | 0.706 | 32.152 | 0.123 |
|  |  | WMn | 0.935(0.904–0.966) | 7.1 × 10− 5 |  |  |  |  |
|  |  | WM | 0.934(0.903–0.966) | 0.001 |  |  |  |  |
Sterol ester (27:1/20:4) levels | 30 | ME | 0.946(0.900-0.994) | 0.036 | -0.007 | 0.261 | 41.839 | 0.058 |
|  |  | WMn | 0.932(0.901–0.965) | 0.000 |  |  |  |  |
|  |  | WM | 0.930(0.898–0.963) | 0.000 |  |  |  |  |