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Table 2 Associations of TyG index and related parameters with aICAS

From: Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis

 

n/N

Model 1*

Model 2*

Model 3*

 

OR (95% CI)

P value

OR (95% CI)

P value

OR (95% CI)

P value

TyG

 Per 1-SD increase

146/2000

1.47 (1.26–1.73)

 < 0.001

1.36 (1.15–1.60)

 < 0.001

1.09 (0.89–1.34)

0.413

Quartiles

 Q1

19/500

1(reference)

 

1(reference)

 

1(reference)

 

 Q2

33/500

1.60 (0.89–2.88)

0.113

1.47 (0.81–2.65)

0.202

1.07 (0.58–1.98)

0.836

 Q3

33/500

1.52 (0.84–2.74)

0.166

1.30 (0.71–2.35)

0.396

0.78 (0.40–1.49)

0.447

 Q4

61/500

3.08 (1.79–5.29)

 < 0.001

2.48 (1.43–4.31)

0.001

1.22 (0.63–2.37)

0.548

 P for trend

  

 < 0.001

 

0.001

 

0.403

TyG-BMI

 Per 1-SD increase

146/2000

1.51 (1.28–1.78)

 < 0.001

1.35 (1.14–1.60)

0.001

1.11 (0.91–1.35)

0.309

Quartiles

 Q1

21/500

1(reference)

 

1(reference)

 

1(reference)

 

 Q2

36/500

1.86 (1.06–3.25)

0.029

1.79 (1.02–3.13)

0.044

1.32 (0.73–2.37)

0.356

 Q3

32/500

1.63 (0.92–2.89)

0.092

1.39 (0.78–2.47)

0.269

0.82 (0.44–1.53)

0.524

 Q4

57/500

3.08 (1.82–5.22)

 < 0.001

2.32 (1.36–3.98)

0.002

1.21 (0.66–2.23)

0.535

 P for trend

  

 < 0.001

 

0.005

 

0.713

TyG-WC

 Per 1-SD increase

146/2000

1.63 (1.38–1.94)

 < 0.001

1.49 (1.25–1.76)

 < 0.001

1.26 (1.03–1.54)

0.022

Quartiles

 Q1

20/500

1(reference)

 

1(reference)

 

1(reference)

 

 Q2

25/500

1.25 (0.68–2.28)

0.477

1.14 (0.62–2.10)

0.669

0.90 (0.48–1.69)

0.747

 Q3

40/500

1.98 (1.14–3.45)

0.015

1.77 (1.01–3.10)

0.045

1.18 (0.65–2.15)

0.580

 Q4

61/500

3.14 (1.86–5.31)

 < 0.001

2.51 (1.47–4.27)

0.001

1.47 (0.81–2.67)

0.208

 P for trend

  

 < 0.001

 

 < 0.001

 

0.079

TyG-WHR

 Per 1-SD increase

146/2000

1.57 (1.33–1.85)

 < 0.001

1.49(1.26–1.76)

 < 0.001

1.29 (1.07–1.55)

0.009

Quartiles

 Q1

24/500

1(reference)

 

1(reference)

 

1(reference)

 

 Q2

23/500

0.94 (0.52–1.69)

0.826

0.84 (0.47–1.53)

0.576

0.67 (0.36–1.26)

0.193

 Q3

43/500

1.84 (1.10–3.09)

0.021

1.67 (0.99–2.81)

0.056

1.13 (0.65–1.97)

0.671

 Q4

56/500

2.32 (1.41–3.82)

0.001

2.04 (1.23–3.38)

0.006

1.23 (0.70–2.16)

0.470

 P for trend

  

 < 0.001

 

 < 0.001

 

0.137

TyG-WHtR

 Per 1-SD increase

146/2000

1.59 (1.34–1.89)

 < 0.001

1.45 (1.22–1.72)

 < 0.001

1.25 (1.04–1.51)

0.021

Quartiles

 Q1

16/500

1(reference)

 

1(reference)

 

1(reference)

 

 Q2

31/500

1.94 (1.04–3.60)

0.036

1.80 (0.97–3.37)

0.064

1.41 (0.74–2.67)

0.299

 Q3

31/500

1.88 (1.01–3.51)

0.047

1.63 (0.87–3.07)

0.128

1.06 (0.54–2.06)

0.876

 Q4

68/500

4.23 (2.37–7.56)

 < 0.001

3.35 (1.86–6.02)

 < 0.001

1.95 (1.02–3.73)

0.043

 P for trend

  

 < 0.001

 

 < 0.001

 

0.024

  1. OR odds ratio, CI confidence interval, aICAS asymptomatic intracranial arterial stenosis, TyG triglyceride-glucose index, BMI body mass index, WC waist circumference, WHR waist-to-hip ratio, WHtR waist-to-height ratio, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, hs-CRP high-sensitivity C-reactive protein
  2. Model 1: adjusted for age, sex
  3. Model 2: additionally adjusted for smoking habit, drinking habit, education, hypertension except for the variables in model 1
  4. Model 3: additionally adjusted for LDL-C, HDL-C, hs-CRP except for the variables in model 2
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Lipids in Health and Disease

ISSN: 1476-511X