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Table 2 Lipoprotein variables of 17 patients with differentiated thyroid carcinoma during hypothyroidism and after 20 weeks of thyroid hormone supplementation

From: Hypothyroidism consequent to thyroidectomy is associated with elevated remnant lipoproteins and cholesterol enrichment of triglyceride-rich lipoproteins: an observational study

Parameter

Hypothyroidism

(TSH range 59–371 mU/L)

Thyroid hormone supplementation

(TSH range 0.01–2.15 mU/L)

Change with 95% CI**

P-value

Total cholesterol (mg/dL)

256 ± 53

154 ± 21

-39 (-43 to -24)

< 0.001

Non-HDL cholesterol (mg/dL)

185 ± 45

98 ± 9

-56 (-51 to -41)

< 0.001

LDL cholesterol (mg/dL)

145 ± 35

79 ± 17

-45 (-49 to -40)

< 0.001

HDL cholesterol (mg/dL)

71 ± 18

52 ± 11

-18 (-24 to -12)

< 0.001

Triglycerides (mg/dL)

138 ± 47

92 ± 26

-31 (-38 to -25)

< 0.001

Apolipoprotein B (mg/L)

130 ± 31

70 ± 13

-45 (-50 to -40)

< 0.001

Total TRL particles (nmol/L)

279 ± 81

111 ± 38

-58 (-66 to -50)

< 0.001

Very large TRL particles (nmol/L)

ND

ND

ND

ND

Large TRL particles (nmol/L)

1.9 ± 2.8

1.5 ± 1.7

-25 (-53 to 3)

0.34

Medium TRL particles (nmol/L)

14.9 ± 12.3

8.7 ± 6.2

-42 (-47 to -35)

0.018

Small TRL particles (nmol/L)

77.6 ± 50.3

36.0 ± 29.2

-42 (-60 to -24)

0.002

Very small TRL particles (nmol/L)

183 ± 76

64 ± 27

-57 (-70 to -45)

< 0.001

TRL size (nm)

41.9 ± 7.2

45.5 ± 8.5

3.7 ( 0.8 to 6.6 )

0.017

TRL cholesterol (mg/dL)

40 ± 13

19 ± 6

-51 (-59 to -43)

< 0.001

TRL triglycerides (mg/dL)

93 ± 44

53 ± 25

-41 (-50 to -32)

< 0.001

TRL cholesterol/triglyceride ratio

0.47 ± 0.12

0.39 ± 0.10

-16 (-23 to -8)

< 0.001

Total LDL particles (nmol/L)*

1991 ± 432

1197 ± 198

-39(-59 to -28)

< 0.001

Large LDL particles (nmol/L)

823 ± 428

363 ± 151

-38 (-67 to -8)

< 0.001

Medium LDL particles (nmol/L)

736 ± 464

292 ± 271

-46 (-72 to -19)

0.002

Small LDL particles (nmol/L)*

502 ± 259

535 ± 232

16 (-5 to 67)

0.67

LDL size (nm)*

21.4 ± 0.5

21.0 ± 0.4

-0.4 (-0.6 to -0.1)

0.004

  1. Data in mean ± SD. *Small LDL particles could not be determined in 1 participant; total LDL particles and LDL size are therefore calculated in 16 participants **Changes are expressed in mean % change with 95% confidence intervals, except for TRL and LDL size for which the differences are in mean with 95% confidence intervals. Statistical comparisons were done by paired T-tests. Abbreviations: CI, Confidence intervals HDL, high density lipoproteins; LDL, low density lipoproteins; ND: not detectable in most participants in any of the study visits; non-HDL cholesterol: non-High Density Lipoprotein cholesterol; TRL, triglyceride-rich lipoproteins; non-HDL cholesterol is calculated as the difference between total and HDL cholesterol. P-values are determined by paired T-test