Parameter | Hypothyroidism (TSH range 59–371 mU/L) | Thyroid hormone supplementation (TSH range 0.01–2.15 mU/L) | Change with 95% CI** | P-value |
---|---|---|---|---|
Total cholesterol (mg/dL) | 256 ± 53 | 154 ± 21 | -39 (-43 to -24) | < 0.001 |
Non-HDL cholesterol (mg/dL) | 185 ± 45 | 98 ± 9 | -56 (-51 to -41) | < 0.001 |
LDL cholesterol (mg/dL) | 145 ± 35 | 79 ± 17 | -45 (-49 to -40) | < 0.001 |
HDL cholesterol (mg/dL) | 71 ± 18 | 52 ± 11 | -18 (-24 to -12) | < 0.001 |
Triglycerides (mg/dL) | 138 ± 47 | 92 ± 26 | -31 (-38 to -25) | < 0.001 |
Apolipoprotein B (mg/L) | 130 ± 31 | 70 ± 13 | -45 (-50 to -40) | < 0.001 |
Total TRL particles (nmol/L) | 279 ± 81 | 111 ± 38 | -58 (-66 to -50) | < 0.001 |
Very large TRL particles (nmol/L) | ND | ND | ND | ND |
Large TRL particles (nmol/L) | 1.9 ± 2.8 | 1.5 ± 1.7 | -25 (-53 to 3) | 0.34 |
Medium TRL particles (nmol/L) | 14.9 ± 12.3 | 8.7 ± 6.2 | -42 (-47 to -35) | 0.018 |
Small TRL particles (nmol/L) | 77.6 ± 50.3 | 36.0 ± 29.2 | -42 (-60 to -24) | 0.002 |
Very small TRL particles (nmol/L) | 183 ± 76 | 64 ± 27 | -57 (-70 to -45) | < 0.001 |
TRL size (nm) | 41.9 ± 7.2 | 45.5 ± 8.5 | 3.7 ( 0.8 to 6.6 ) | 0.017 |
TRL cholesterol (mg/dL) | 40 ± 13 | 19 ± 6 | -51 (-59 to -43) | < 0.001 |
TRL triglycerides (mg/dL) | 93 ± 44 | 53 ± 25 | -41 (-50 to -32) | < 0.001 |
TRL cholesterol/triglyceride ratio | 0.47 ± 0.12 | 0.39 ± 0.10 | -16 (-23 to -8) | < 0.001 |
Total LDL particles (nmol/L)* | 1991 ± 432 | 1197 ± 198 | -39(-59 to -28) | < 0.001 |
Large LDL particles (nmol/L) | 823 ± 428 | 363 ± 151 | -38 (-67 to -8) | < 0.001 |
Medium LDL particles (nmol/L) | 736 ± 464 | 292 ± 271 | -46 (-72 to -19) | 0.002 |
Small LDL particles (nmol/L)* | 502 ± 259 | 535 ± 232 | 16 (-5 to 67) | 0.67 |
LDL size (nm)* | 21.4 ± 0.5 | 21.0 ± 0.4 | -0.4 (-0.6 to -0.1) | 0.004 |