Fig. 6
From: High-fat stimulation induces atrial structural remodeling via the TPM1/P53/SHISA5 Axis
The TPM1/P53/SHISA5 axis mediates ER stress and autophagy. WB detection of cytoplasmic and nuclear P53 protein expression in HCF cells after rTPM1 stimulation (A). WB detection of P53, SHISA5, Collagen I, MMP2, p-IRE1α, GRP78, p-JNK, P62, LC3-II protein expression in HCF cells after activation of P53 by C16-ceramide stimulation (B). WB detection of Collagen I, p-IRE1α, GRP78, MMP2, P62, p-JNK, SHISA5, LC3-II protein expression after ADV-SHISA5 transfection in HCF cells (C)