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Table 4 Mediating effect of TyG index and eGFR in the relationship between SMD and hypertension in patients with SLE

From: Association between myosteatosis or sarcopenia based on abdominal CT and hypertension in systemic lupus erythematosus patients

Model Pathways

Effect size

Boot SE

Boot CI

Lower

Upper

Direct effect

0.1886

0.1358

-0.0797

0.4528

Total indirect effect

0.1403

0.0750

0.0354

0.3272

Indirect 1

0.0071

0.0322

-0.0576

0.0759

Indirect 2

0.1121

0.0666

0.0177

0.2765

Indirect 3

0.0211

0.0150

0.0032

0.0614

  1. Adjusted for age, sex, disease duration, immunosuppressant, glucocorticoid, neutrophil, lymphocyte, monocyte, A/G, GLU, LDLc, HDLc
  2. Note. SMD in per 5-HU reduction. Indirect effect 1: SMD–TyG index–hypertension; Indirect effect 1: SMD–eGFR–hypertension; Indirect effect 1: SMD–TyG index–eGFR–hypertension
  3. Abbreviation: SLE, systemic lupus erythematosus; SMD, skeletal muscle radiodensity; eGFR, estimated glomerular filtration rate; TyG index, triglyceride-glucose index; A/G, albumin-globulin ratio; GLU, blood glucose; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol
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Lipids in Health and Disease

ISSN: 1476-511X