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Table 1 Baseline characteristics of hypertensive patients stratified by Chinese-modified DLCN criteria

From: Familial hypercholesterolemia in patients with hypertension: the China H-type Hypertension Registry Study

 

Unlikely FH

Possible FH

Probable + Definite FH

P value

(n = 8,367)

(n = 2,455)

(n = 78)

Demographic factor

 Female, n (%)**

4076 (48.7%)

1545 (62.9%)

54 (69.2%)

< 0.001

 Age, years**

65 [58, 71]

63 [56, 69]

61 [54, 67]

< 0.001

 Smoking, n %%)***

3861 (46.1%)

843 (34.3%)

22 (28.2%)

< 0.001

 Drinking, n (%)

2808 (33.6%)

668 (27.2%)

19 (24.4%)

< 0.001

Family history

 CHD, n (%)***

538 (6.4%)

184 (7.5%)

27 (34.6%)

< 0.001

 Stroke, n (%)***

841 (10.1%)

283 (11.5%)

26 (33.3%)

< 0.001

 Hypertension, n (%)**

4108 (50.5%)

1312 (54.7%)

50 (67.6%)

< 0.001

Drug usage

 LLT, n (%)***

219 (2.6%)

135 (5.5%)

28 (35.9%)

< 0.001

 Antidiabetic Drug, n (%)*

394 (4.7%)

126 (5.1%)

9 (11.5%)

0.015

 Antihypertensive Drugs, n (%)

5162 (61.7%)

1533 (62.4%)

55 (70.5%)

0.234

Personal history

 Cancer, n (%)

99 (1.2%)

33 (1.3%)

1 (1.3%)

0.814

 Heart Failure, n (%)

99 (1.2%)

28 (1.1%)

1 (1.3%)

0.981

 CHD, n (%)***

435 (5.2%)

170 (6.9%)

24 (30.8%)

< 0.001

 Stroke, n (%)***

591 (7.1%)

187 (7.6%)

16 (20.5%)

< 0.001

 Diabetes, n (%)**

658 (7.9%)

238 (9.7%)

15 (19.2%)

< 0.001

Physical examination

 BMI **

23.08 [20.73, 25.53]

24.38 [22.28, 26.58]

24.42 [22.09, 27.31]

< 0.001

 Waist circumference, cm

83.10 [76.10, 89.90]

86.60 [80.30, 92.50]

85.95 [79.00, 91.13]

< 0.001

 Hip circumference, cm*

91.50 [87.20, 96.00]

93.00 [89.20, 97.30]

93.90 [89.23, 96.85]

< 0.001

 baPWV, cm/s

1784.00 [1568.25, 2058.00]

1818.00 [1585.00, 2077.00]

1729.00 [1567.00, 1985.00]

0.16

 ABI

1.11 [1.06, 1.16]

1.10 [1.04, 1.15]

1.08 [1.00, 1.13]

< 0.001

 SBP, mmHg

145.67 [135.00, 157.33]

146.67 [136.67, 158.67]

147.67 [138.84, 158.42]

0.002

 DBP, mmHg

88.67 [81.00, 95.00]

90.00 [83.00, 96.33]

89.00 [80.75, 96.92]

< 0.001

 Heart rate*

74.67 [67.00, 83.33]

77.33 [69.67, 86.00]

76.34 [67.67, 84.17]

< 0.001

Blood examination

 TC, mmol/L***

4.76 [4.17, 5.30]

6.28 [5.85, 6.82]

7.72 [6.61, 9.18]

< 0.001

 TG, mmol/L***

1.34 [0.96, 1.99]

1.92 [1.43, 2.62]

2.24 [1.72, 3.20]

< 0.001

 HDL-C, mmol/L***

1.43 [1.19, 1.71]

1.55 [1.35, 1.81]

1.68 [1.42, 2.04]

< 0.001

 LDL-C, mmol/L***

2.67 [2.26, 3.04]

3.86 [3.63, 4.19]

5.14 [4.21, 6.07]

< 0.001

 Glucose, mmol/L***

5.71 [5.32, 6.27]

6.10 [5.58, 6.96]

6.70 [5.83, 8.78]

< 0.001

 HCY, μmol/L

14.90 [12.40, 19.19]

15.08 [12.59, 19.01]

15.16 [12.81, 19.24]

0.231

 AST, U/L**

24.00 [20.00, 29.00]

25.00 [21.00, 32.00]

28.00 [22.00, 35.75]

< 0.001

 ALT, U/L***

16.0 [12.0, 23.0]

19.0 [14.0, 27.5]

22.5 [15.0, 32.0]

< 0.001

 Uric acid, μmol/L

410.00 [338.00, 495.00]

429.00 [357.00, 517.00]

403.00 [356.25, 544.00]

< 0.001

 Urea nitrogen, mmol/L

5.13 [4.20, 6.25]

5.24 [4.28, 6.34]

5.38 [4.48, 6.86]

0.027

 Creatinine, μmol/L

69.00 [57.00, 84.00]

67.00 [56.00, 81.00]

65.00 [57.00, 83.75]

0.01

 GGT, U/L***

21.0 [15.0, 32.0]

25.0 [17.0, 42.0]

30.5 [19.0, 45.5]

< 0.001

 ALB, g/L*

45.90 [43.50, 48.20]

47.40 [45.20, 49.90]

47.15 [45.10, 50.27]

< 0.001

 eGFR, ml/min/1.73m2

90.52 [75.75, 99.26]

90.86 [75.69, 99.27]

91.83 [78.17, 100.37]

0.751

  1. CHD Coronary heart disease, LLT Lipid-lowering therapy, BMI Body mass index, baPWV brachia-ankle pulse wave velocity, ABI Ankle-brachial index, SBP Systolic blood pressure, DBP Diastolic blood pressure, TC Total cholesterol, TG Triglyceride, HDL-C High-density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, HCY Homocysteine, AST Aspartate aminotransferase, ALT Alanine aminotransferase, GGT Gamma-glutamyl transpeptidase, ALB Albumin, eGFR estimated glomerular filtration rate
  2. *, **, *** represent p < 0.05, p < 0.01, p < 0.001 respectively in comparison between FH (probable + definite) and non-FH (unlikely + possible)
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Lipids in Health and Disease

ISSN: 1476-511X