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Table 2 Summary of pathways/gene sets, genes and lipids related to MDD, BD, SCZ, and OCD

From: Lipidomics and genomics in mental health: insights into major depressive disorder, bipolar disorder, schizophrenia, and obsessive-compulsive disorder

Disorder

Pathways/Gene Sets

Genes/SNPs

Lipids

Major Depressive Disorder

tricarboxylic acid cycle/energy metabolism

FADS2

rs174564

rs12721109 (APOC4 gene)

TG, HDL, LDL, TC, VLDL, IDL, ↑MUFA, ↓PUFA and ↓ omega-6 FA, omega-3 FA, ↓ APOA, ↓sphingomyelins, 2-aminooctanoate, 10-undecenoate (11:1n1), 1-palmitoyl-2-palmitoleoyl-GPC (16:0/16:1),1-linoleoyl-GPA (18:2), docosahexaenoic acid, 3-Hydroxybutyrate

Bipolar Disorder

lipids biosynthetic process, unsaturated FA biosynthesis, chylomicrons and triglyceride-rich lipoprotein particles, protein-lipid complexes, omega-3 FA

ABCA13

rs174592-G (FADS cluster gene)

Arachidonic Acid, Hexanoylcarnitine, N-acetylornithine, 1-arachidonoylglycerophosphocholine

Schizophrenia

LDL and VLDL, LXR/RXR, glycerolipids, phospholipids, glycerophospholipids, FA, cardiometabolic and inflammation-related traits

ABCA13, LPL (rs253-CC), FADS cluster gene, APOC3, APOH, APOB, DGKZ (rs7851870-TT)

VLDL, HDL, TG, LDL, TC, FA, short-chain PUFA, ↑Cer, ↑PC, ↑TG, ↓ CAR and ↓ PC-P, PC ae C38:6, 3OSG, estrone, cholesterol sulfate, 16A OH-Preg, DHT, A4, Vitamin D3, androsterone sulfate, N-acetylornithine, Butyrylcarnitine

Obsessive–Compulsive Disorder

Peroxisomal lipids, sphingolipids, lipophilic vitamins

  
  1. Abbreviations: ↑ increased blood levels, ↓ decreased blood levels, 16A OH-Preg 16-alpha-hydroxypregnenolone, 3OSG 3-O-sulfogalactosylceramide, A4 androstenedione, ABCA13 ATP binding cassette subfamily A Member 13, APOA1 apolipoprotein A1, APOB apolipoprotein B, APOC3 apolipoprotein C3, APOH apolipoprotein H, CAR acylcarnitine, Cer ceramides, DGKZ diacylglycerol kinase zeta, DHT dihydrotestosterone, FA fatty acids, FADS fatty acid desaturase, FADS2 Fatty Acid Desaturase 2, HDL high-density lipoprotein, IDL intermediate-density lipoprotein, LDL low-density lipoprotein, MUFA monounsaturated fatty acids, PC-P phosphatidylcholine plasmalogen, PC phosphatidylcholine, PUFA polyunsaturated fatty acids, TC total cholesterol, TG triglycerides, VLDL very low-density lipoproteins
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Lipids in Health and Disease

ISSN: 1476-511X