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Table 3 Four-way decomposition of the association between BMI and PHQ-9 score mediated by NHHR

From: The joint and interactive effects of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and body mass index on the risk of depression, as well as the mediating role of NHHR: results from NHANES 2005–2023

Effect

Estimates (95% CI)

P-value

Proportion

TE

0.427 (0.376–0.478)

< 0.001

100%

CDE

0.378 (0.326–0.431)

< 0.001

88.5%

INTref

0.002 (0.000-0.003)

0.105

0.5%

INTmed

0.012 (-0.002-0.026)

0.091

2.8%

PIE

0.035 (0.020–0.049)

< 0.001

8.2%

  1. Model was adjusted for age, gender, race, education level, marriage status, PIR, daily activities smoking status, drinking status, hypertension, diabetes and CVD
  2. Abbreviations: NHHR: non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio; BMI: body mass index; PHQ-9: Patient Health Questionnaire 9; CI, confidence interval; TE: total effect; CDE: controlled direct effect; INTref: reference interaction; INTmed: mediated interaction; PIE: pure indirect effect; PIR: poverty income ratio; CVD: cardiovascular disease
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Lipids in Health and Disease

ISSN: 1476-511X