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Table 2 Four-way decomposition of the association between BMI and depression mediated by NHHR

From: The joint and interactive effects of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and body mass index on the risk of depression, as well as the mediating role of NHHR: results from NHANES 2005–2023

Effect

Estimates (95% CI)

P-value

Proportion

TE

0.199 (0.152–0.245)

< 0.001

100%

CDE

0.162 (0.116–0.208)

< 0.001

81.4%

INTref

0.002 (-0.003-0.008)

0.382

1.0%

INTmed

0.007 (-0.004-0.017)

0.240

3.5%

PIE

0.028 (0.016–0.040)

< 0.001

14.1%

  1. Model was adjusted for age, gender, race, education level, marriage status, PIR, daily activities smoking status, drinking status, hypertension, diabetes and CVD
  2. Abbreviations: NHHR: non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio; BMI: body mass index; CI, confidence interval; TE: total effect; CDE: controlled direct effect; INTref: reference interaction; INTmed: mediated interaction; PIE: pure indirect effect; PIR: poverty income ratio; CVD: cardiovascular disease
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Lipids in Health and Disease

ISSN: 1476-511X