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Table 1 Baseline characteristics of the participants based on depression status

From: The joint and interactive effects of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and body mass index on the risk of depression, as well as the mediating role of NHHR: results from NHANES 2005–2023

Characteristic

Overall

PHQ-9 < 10

PHQ-9 ≥ 10

P-valuea

(N = 39,704)

(N = 36,055)

(N = 3,649)

Age, years

50.09 (17.64)

50.21 (17.76)

48.90 (16.41)

< 0.001

Age group

   

< 0.001

 20–44

16,169 (40.7%)

14,683 (40.7%)

1,486 (40.7%)

 

 45–65

14,427 (36.3%)

12,883 (35.7%)

1,544 (42.3%)

 

 > 65

9,108 (22.9%)

8,489 (23.5%)

619 (17.0%)

 

Gender

   

< 0.001

 Female

20,397 (51.0%)

18,077 (50.1%)

2,320 (63.6%)

 

 Male

19,307 (48.6%)

17,978 (49.9%)

1,329 (36.4%)

 

Race

   

< 0.001

 Mexican American

5,684 (14.3%)

5,188 (14.4%)

496 (13.6%)

 

 Non-Hispanic Black

7,967 (20.1%)

7,210 (20.0%)

757 (20.7%)

 

 Non-Hispanic White

17,951 (45.2%)

16,335 (45.3%)

1,616 (44.3%)

 

 Other Hispanic

3,891 (9.8%)

3,420 (9.5%)

471 (12.9%)

 

 Other Race

4,211 (10.6%)

3,902 (10.8%)

309 (8.5%)

 

Education levelb

   

< 0.001

 High school or below

17,689 (44.6%)

15,658 (43.5%)

2,031 (55.7%)

 

 University or above

21,993 (55.4%)

20,377 (56.5%)

1,616 (44.3%)

 

Marriage statusb

   

< 0.001

 Never married

4,922 (12.4%)

4,431 (12.3%)

491 (13.5%)

 

 Married/Living with partner

23,578 (59.4%)

21,377 (60.9%)

1,627 (44.6%)

 

 Widowed/Divorced/Separated

11,183 (28.2%)

9,655 (26.8%)

1,528 (41.9%)

 

PIRb

   

< 0.001

 < 1

7,052 (19.5%)

5,883 (17.9%)

1,169 (35.5%)

 

 ≥ 1

29,069 (80.5%)

26,942 (82.1%)

2,127 (64.5%)

 

Daily activitiesb

   

< 0.001

 Moderate

25,544 (64.3%)

22,943 (63.8%)

2,601 (71.7%)

 

 Vigorous

14,015 (35.4%)

12,990 (36.2%)

1,025 (28.3%)

 

Smoking statusb

   

< 0.001

 Never

22,239 (56.0%)

20,669 (57.4%)

1,570 (43.0%)

 

 Smoking at present

7,626 (19.2%)

6,385 (17.7%)

1,241 (34.0%)

 

 Smoking cessation

9,813 (24.7%)

8,977 (24.9%)

836 (22.9%)

 

Drinking statusb

   

0.314

 No

8,903 (22.4%)

8,110 (22.5%)

793 (21.8%)

 

 Yes

30,763 (77.6%)

27,913 (77.5%)

2,850 (78.2%)

 

Diabetesb

   

< 0.001

 No

32,274 (82.9%)

29,588 (83.6%)

2,686 (75.3%)

 

 Yes

6,665 (17.1%)

5,786 (16.4%)

879 (24.7%)

 

Hypertensionb

   

< 0.001

 No

21,502 (54.2%)

19,778 (54.9%)

1,724 (47.2%)

 

 Yes

18,199 (45.8%)

16,274 (45.1%)

1,925 (52.8%)

 

CVDb

   

< 0.001

 No

35,219 (89.1%)

32,280 (89.9%)

2,939 (81.3%)

 

 Yes

4,316 (10.9%)

3,638 (10.1%)

678 (18.7%)

 

BMI, kg/m2

29.42 (7.05)

29.25 (6.87)

31.19 (8.38)

< 0.001

BMI group

   

< 0.001

 < 25

10,951 (27.6%)

10,097 (28.0%)

854 (23.4%)

 

 25–30

13,284 (33.5%)

12,296 (34.1%)

988 (27.1%)

 

 > 30

15,469 (38.9%)

13,662 (37.9%)

1,807 (49.5%)

 

TC, mg/dl

192.08 (42.12)

191.94 (41.85)

193.48 (44.68)

0.035

HDL-C, mg/dl

53.37 (16.08)

53.53 (16.10)

51.75 (15.82)

< 0.001

NHHR

2.88 (1.41)

2.86 (1.40)

3.04 (1.56)

< 0.001

 Q1 (0.28–1.89)

9,933 (25.0%)

9,140 (25.4%)

793 (21.7%)

 

 Q2 (1.90–2.61)

10,003 (25.2%)

9,160 (25.4%)

843 (23.1%)

 

 Q3 (2.62–3.55)

9,853 (24.8%)

8,878 (24.6%)

975 (26.7%)

 

 Q4 (3.56-27.00)

9,915 (25.0%)

8,877 (24.6%)

1,038 (28.4%)

 

NHHR-BMIc

86.82 (51.22)

85.79 (50.18)

97.00 (59.66)

< 0.001

 Q1 (8.00-50.48)

9,929 (25.0%)

9,194 (25.5%)

735 (20.1%)

 

 Q2 (50.49–76.33)

9,925 (25.0%)

9,152 (25.4%)

773 (21.2%)

 

 Q3 (76.34-111.06)

9,924 (25.0%)

8,950 (24.8%)

974 (26.7%)

 

 Q4 (111.07-922.78)

9,926 (25.0%)

8,759 (24.3%)

1,167 (32.0%)

 
  1. aP-value was calculated by T-test or Chi-square test where appropriate
  2. b Missing data: 22 for education level, 21 for marriage status, 3,583 for PIR, 145 for daily activities, 26 for smoking status, 38 for drinking status, 765 for diabetes disease, 3 for hypertension, 169 for history of CVD
  3. c The NHHR-BMI was the product of NHHR and BMI
  4. Mean (SD) was used to describe continuous variables, proportions were used to describe categorical variables
  5. Abbreviations: PHQ-9: Patient Health Questionnaire 9; PIR: poverty income ratio; CVD: Cardiovascular disease; BMI: body mass index; TC: total cholesterol; HDL-C: high-density lipoprotein cholesterol; NHHR: non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio