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Fig. 2 | Lipids in Health and Disease

Fig. 2

From: The joint and interactive effects of the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and body mass index on the risk of depression, as well as the mediating role of NHHR: results from NHANES 2005–2023

Fig. 2

Schematic representation of the interaction and mediation analysis framework

Legends: A, directed acyclic graph (DAG). B, four-way decomposition diagram. X, BMI as the exposure variable. M, NHHR as the mediator variable. Y, depression or PHQ-9 score as the outcome. C, covariate. X*M, interaction term between the independent variable and the mediator variable. Abbreviation: TE: total effect; CDE: controlled direct effect; INTref: reference interaction; INTmed: mediated interaction; PIE: pure indirect effect

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Lipids in Health and Disease

ISSN: 1476-511X