Skip to main content

Table 1 Baseline demographic and clinical characteristics of patients in the derivation set and the validation set

From: A LASSO-derived model for the prediction of nonattainment of target LDL-C reduction with PCSK9 inhibitors in patients with atherosclerotic cardiovascular disease

Variables

The derivation set (n = 523)

The validation set (n = 225)

P-value

Demographics

 Age (years)a

56(48, 65)

58(49, 65)

0.075

 Male sex, n (%)

402(76.9)

185(82.2)

0.102

 Smoker, n (%)

161(30.8)

73(32.4)

0.653

 Drinker, n (%)

136(26.0)

56(24.9)

0.749

 BMI (kg/m2) a

26.1(24.3, 28.7)

26.0(24.2, 28.4)

0.483

 SBP, mmHg

129(120, 138)

132(120, 141)

0.181

 DBP, mmHg

77(70, 84)

77(70, 84)

0.997

Comorbidities, n (%)

 Hypertension

305(58.3)

146(64.9)

0.092

 Hyperlipemia

475(90.8)

210(93.3)

0.257

 T2DM

163(31.2)

85(37.8)

0.078

 Hyperuricemia

22(4.2)

11(4.9)

0.677

 Prior MI

80(15.3)

28(12.4)

0.309

 Prior cerebral infarction

48(9.2)

11(4.9)

0.046

Laboratory examination s at admissiona

 eGFR (mL/min)

93.9(85.8, 102.1)

93.9(82.8, 100.7)

0.208

 SCr (μmol/L)

76.4(68.2, 84.9)

76.4(70.7, 86.4)

0.182

 UA (μmol/L)

347.1(298.4, 402.1)

347.1(302.3, 392.3)

0.551

 PLT (*109/L)

219(195, 246)

219(188, 249)

0.646

 ALT (U/L)

20(15, 28)

20(17, 29)

0.121

 AST (U/L)

19(16, 23)

19(17, 24)

0.089

 TG (mmol/L)

1.55(1.21, 2.18)

1.54(1.19, 1.99)

0.224

 TC (mmol/L)

4.26(3.45, 5.24)

4.26(3.60, 4.94)

0.826

 HDL-C (mmol/L)

1.02(0.89, 1.18)

1.02(0.91, 1.16)

0.567

 LDL-C (mmol/L)

2.41(1.77, 3.20)

2.41(1.91, 3.02)

0.982

Concomitant medication, n (%)

 Statins

508(97.1)

219(97.3)

0.878

 Ezetimibe

129(24.7)

54(24.0)

0.846

  1. Abbreviations: BMI Body mass index, SBP Systolic blood pressure, DBP Diastolic blood pressure, T2DM Diabetes mellitus type 2, MI Myocardial infarction, eGFR estimated glomerular filtration rate, SCr Serum creatinine, UA Uric acid, BNP B-type natriuretic peptide, PLT Platelet, AST Aspartate amino transferase, ALT Alanine transaminase, TG Triglyceride, TC Total cholesterol, HDL-C High-density lipoprotein cholesterol, LDL-C Low-density lipoprotein cholesterol
  2. aContinuous data are expressed as median (interquartile range) and were calculated by Mann–Whitney U-test; Categorical data were presented as count (percentage) and were calculated by chi-squared test