Skip to main content
Fig. 4 | Lipids in Health and Disease

Fig. 4

From: Plasma lipidomic analysis reveals disruption of ether phosphatidylcholine biosynthesis and facilitates early detection of hepatitis B-related hepatocellular carcinoma

Fig. 4

Validation of altered ether PC biosynthesis by multi-omic analysis. Comparison of RNA levels (A) and protein levels (B) of key enzymes involved in ether PC biosynthesis between primary HCC tissue samples and normal controls in TCGA datasets and CPTAC datasets, respectively (***, P < 0.001; ****, P < 0.0001). Graphic illustration of molecular dysregulation in ether PC biosynthesis in HCC (C). Upregulated enzymes are marked in red and downregulated are marked in blue. PEMT, phosphatidylethanolamine N-methyltransferase; AGPS, alkyl DHAP synthase; CHPT1, choline phosphotransferase 1; GNPAT: DHAP acyltransferase; Far1/2, fatty acyl-CoA reductase 1 or 2

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X