Fig. 3

Major lipid classes potentially correlated with hepatocarcinogenesis. Mfuzz clustering for variation pattern along the trajectory of CHB-LC-HCC using all identified lipid features in ESI + mode (A) or ESI- mode (B). Bar plot illustration of the feature number of each lipid class in clusters with consecutive decline (C) and elevation (D) in the trajectory of CHB-LC-HCC and heatmap illustration of ether PC and PC levels in selected clusters, along with clinical characteristics of Age, sex, sAg and AFP (E)