Sex differences in associations of metabolic inflammation and insulin resistance with incident type 2 diabetes mellitus: a retrospective cohort of adults with annual health examinations

Table 4 Associations of the TyG-BMI, LHR, MHR and NHR with incident type 2 diabetes mellitus in sensitivity analysis cohort 1 (N = 775)

		Cox proportional hazards model ^a			Logistic regression model ^a
		HR(95% CI)	P	P _interaction	OR(95% CI)	P	P _interaction
TyG-BMI^b	Total	1.07(0.97,1.18)	0.192	0.677	1.08(0.97,1.20)	0.179	0.675
	Male	1.10(0.93,1.29)	0.261		1.10(0.93,1.30)	0.248
	Female	1.06(0.93,1.21)	0.382		1.07(0.93,1.23)	0.363
LHR	Total	1.75(1.02,2.99)	0.042	0.030	1.84(1.04,3.26)	0.037	0.020
	Male	0.79(0.30,2.08)	0.628		0.78(0.29,2.11)	0.622
	Female	2.67(1.41,5.06)	0.003		3.13(1.51,6.46)	0.002
MHR	Total	6.22(0.68,56.52)	0.104	0.150	7.60(0.68,84.69)	0.099	0.124
	Male	1.20(0.03,48.50)	0.924		1.21(0.03,55.08)	0.923
	Female	34.50(1.46,814.76)	0.028		57.10(1.65,1978.95)	0.025
NHR	Total	1.27(0.96,1.68)	0.088	0.038	1.31(0.97,1.77)	0.081	0.024
	Male	0.75(0.41,1.37)	0.345		0.74(0.40,1.37)	0.337
	Female	1.49(1.12,1.99)	0.006		1.65(1.15,2.37)	0.006

Abbreviations: TyG-BMI triglyceride glucose-body mass index, LHR lymphocyte-high density lipoprotein cholesterol ratio, MHR monocyte-high density lipoprotein cholesterol ratio, NHR neutrophil-high density lipoprotein cholesterol ratio
^aThe adjusted models were adjusted for sex (male as reference) and age
^bTyG-BMI was converted to one-tenth of its original value

ISSN: 1476-511X