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Table 1 Description of baseline characteristics for the overall participants and for the groups by RC quintiles

From: Remnant cholesterol and risk of aortic aneurysm and dissection: a prospective cohort Study from the UK biobank study and mendelian randomization analysis

 

RC quintiles

P

Characteristics

Total participants (n = 368,139)

Quintile 1 (n = 73,753)

Quintile 2 (n = 73,613)

Quintile 3 (n = 73,568)

Quintile 4 (n = 73,600)

Quintile 5 (n = 73,605)

 

Sex (%)

      

 < 0.001

 Female

195,782 (53.18)

49,555 (67.19)

44,581 (60.56)

39,874 (54.20)

34,545 (46.94)

27,227 (36.99)

 

 Male

172,357 (46.82)

24,198 (32.81)

29,032 (39.44)

33,694 (45.80)

39,055 (53.06)

46,378 (63.01)

 

 Age (median [IQR])

58.000 [50.000, 63.000]

54.000 [47.000, 61.000]

58.000 [50.000, 63.000]

59.000 [51.000, 64.000]

59.000 [52.000, 64.000]

58.000 [51.000, 63.000]

 < 0.001

Ethnic (%)

      

 < 0.001

 Others

17,952 (4.88)

4860 (6.59)

3674 (4.99)

3222 (4.38)

3106 (4.22)

3090 (4.20)

 

 White

350,187 (95.12)

68,893 (93.41)

69,939 (95.01)

70,346 (95.62)

70,494 (95.78)

70,515 (95.80)

 

Smoking (%)

      

 < 0.001

 No

200,359 (54.42)

44,349 (60.13)

42,074 (57.16)

40,324 (54.81)

37,895 (51.49)

35,717 (48.53)

 

 Yes

167,780 (45.58)

29,404 (39.87)

31,539 (42.84)

33,244 (45.19)

35,705 (48.51)

37,888 (51.47)

 

Drinking (%)

      

 < 0.001

 No

181,136 (49.20)

32,988 (44.73)

35,268 (47.91)

36,806 (50.03)

37,798 (51.36)

38,276 (52.00)

 

 Yes

187,003 (50.80)

40,765 (55.27)

38,345 (52.09)

36,762 (49.97)

35,802 (48.64)

35,329 (48.00)

 

Body mass index (%):

      

 < 0.001

 < 18.50

1875 (0.51)

1020 (1.38)

468 (0.64)

225 (0.31)

112 (0.15)

50 (0.07)

 

 18.50–24.99

120,507 (32.73)

40,768 (55.28)

30,344 (41.22)

22,790 (30.98)

16,139 (21.93)

10,466 (14.22)

 

 25.00–29.99

157,478 (42.78)

24,634 (33.40)

30,283 (41.14)

33,161 (45.08)

34,353 (46.68)

35,047 (47.61)

 

 > = 30.00

88,279 (23.98)

7331 (9.94)

12,518 (17.01)

17,392 (23.64)

22,996 (31.24)

28,042 (38.10)

 

Lipid parameters, median [IQR], mmol/L

     

 < 0.001

 LDL-C

3.451 [2.811, 4.109]

3.189 [2.665, 3.757]

3.455 [2.856, 4.060]

3.546 [2.897, 4.193]

3.564 [2.872, 4.254]

3.555 [2.822, 4.267]

 

 TC

5.652 [4.908, 6.422]

5.254 [4.621, 5.936]

5.535 [4.845, 6.242]

5.676 [4.943, 6.399]

5.790 [5.025, 6.569]

6.085 [5.279, 6.894]

 

 TG

1.480 [1.043, 2.143]

0.790 [0.680, 0.880]

1.124 [1.044, 1.206]

1.480 [1.382, 1.584]

1.969 [1.823, 2.140]

2.944 [2.578, 3.559]

 

 HDL-C

1.401 [1.173, 1.677]

1.671 [1.426, 1.954]

1.531 [1.305, 1.790]

1.411 [1.207, 1.652]

1.298 [1.116, 1.511]

1.167 [1.012, 1.352]

 

 RC

0.672 [0.474, 0.967]

0.359 [0.309, 0.400]

0.511 [0.475, 0.548]

0.672 [0.628, 0.720]

0.892 [0.828, 0.967]

1.297 [1.161, 1.496]

 

Education (%)

      

 < 0.001

 Low

58,386 (15.86)

8326 (11.29)

10,777 (14.64)

12,321 (16.75)

13,261 (18.02)

13,701 (18.61)

 

 Medium

186,508 (50.66)

36,079 (48.92)

37,063 (50.35)

37,292 (50.69)

37,691 (51.21)

38,383 (52.15)

 

 High

123,245 (33.48)

29,348 (39.79)

25,773 (35.01)

23,955 (32.56)

22,648 (30.77)

21,521 (29.24)

 

Activity (%)

      

 < 0.001

 Healthy activity

255,045 (69.28)

53,730 (72.85)

52,289 (71.03)

51,090 (69.45)

49,591 (67.38)

48,345 (65.68)

 

 Unhealthy activity

113,094 (30.72)

20,023 (27.15)

21,324 (28.97)

22,478 (30.55)

24,009 (32.62)

25,260 (34.32)

 

Diet (%)

      

 < 0.001

 Healthy diet

57,387 (15.59)

13,349 (18.10)

12,421 (16.87)

11,507 (15.64)

10,768 (14.63)

9342 (12.69)

 

 Unhealthy diet

310,752 (84.41)

60,404 (81.90)

61,192 (83.13)

62,061 (84.36)

62,832 (85.37)

64,263 (87.31)

 

Peripheral vascular disease (%)

     

0.031

 No

366,935 (99.67)

73,526 (99.69)

73,387 (99.69)

73,352 (99.71)

73,326 (99.63)

73,344 (99.65)

 

 Yes

1204 (0.33)

227 (0.31)

226 (0.31)

216 (0.29)

274 (0.37)

261 (0.35)

 

Coronary heart disease (%)

      

 No

353,612 (96.05)

71,652 (97.15)

70,983 (96.43)

70,583 (95.94)

70,205 (95.39)

70,189 (95.36)

 < 0.001

 Yes

14,526 (3.95)

2101 (2.85)

2630 (3.57)

2985 (4.06)

3394 (4.61)

3416 (4.64)

 

Coronary atherosclerosis (%)

     

 < 0.001

 No

367,759 (99.90)

73,701 (99.93)

73,548 (99.91)

73,508 (99.92)

73,491 (99.85)

73,511 (99.87)

 

 Yes

380 (0.10)

52 (0.07)

65 (0.09)

60 (0.08)

109 (0.15)

94 (0.13)

 

Stroke (%)

      

0.035

 No

366,271 (99.49)

73,386 (99.50)

73,286 (99.56)

73,198 (99.50)

73,198 (99.45)

73,203 (99.45)

 

 Yes

1868 (0.51)

367 (0.50)

327 (0.44)

370 (0.50)

402 (0.55)

402 (0.55)

 

Diabetes (%)

      

 < 0.001

 No

360,508 (97.93)

72,687 (98.55)

72,486 (98.47)

72,139 (98.06)

71,715 (97.44)

71,481 (97.11)

 

 Yes

7630 (2.07)

1066 (1.45)

1127 (1.53)

1429 (1.94)

1884 (2.56)

2124 (2.89)

 

Hypertension (%)

      

 < 0.001

 No

162,789 (44.22)

43,675 (59.22)

36,151 (49.11)

31,452 (42.75)

27,315 (37.11)

24,196 (32.87)

 

 Yes

205,350 (55.78)

30,078 (40.78)

37,462 (50.89)

42,116 (57.25)

46,285 (62.89)

49,409 (67.13)

 

Medication intake, n (%)

      

 < 0.001

 Antidiabetic drugs

  No

246,160 (99.30)

54,754 (98.98)

51,329 (99.42)

48,632 (99.38)

45,912 (99.41)

45,533 (99.37)

 

  Yes

1731 (0.70)

566 (1.02)

300 (0.58)

302 (0.62)

273 (0.59)

290 (0.63)

 

 Antihypertensive drugs

  No

246,160 (75.59)

54,754 (84.18)

51,329 (79.01)

48,632 (74.73)

45,912 (70.52)

45,533 (69.57)

 

  Yes

79,481 (24.41)

10,290 (15.82)

13,639 (20.99)

16,444 (25.27)

19,194 (29.48)

19,914 (30.43)

 

 Cholesterol-lowering drugs

  No

246,160 (79.16)

54,754 (86.38)

51,329 (82.24)

48,632 (78.68)

45,912 (74.61)

45,533 (73.68)

 

  Yes

64,788 (20.84)

8636 (13.62)

11,086 (17.76)

13,178 (21.32)

15,621 (25.39)

16,267 (26.32)

 
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Lipids in Health and Disease

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