Table 2 Characteristics of included patients stratified by LHR tertiles
Variables | Total (n = 873) | T1 (n = 287) | T2 (n = 293) | T3 (n = 293) | p-value |
|---|---|---|---|---|---|
LHR | 1.7 (1.2, 2.4) | 1.0 (0.8, 1.2) | 1.7 (1.6, 1.9) | 2.8 (2.4, 3.4) | < 0.001 |
Demographic variables | |||||
 Age, years | 71 (60, 81) | 75 (65, 83) | 74 (61, 82) | 65 (54, 75) | < 0.001 |
 Weight, kg | 77.8 (64.5, 93) | 71.2 (59.8, 84) | 77.8 (63.8, 93) | 84 (72, 99.3) | < 0.001 |
 Male | 472 (54.1) | 135 (47) | 161 (54.9) | 176 (60.1) | 0.007 |
 Ethnicity (White) | 482 (55.2) | 167 (58.2) | 167 (57) | 148 (50.5) | 0.134 |
Clinical severity | |||||
 GCS | 12 (8, 14) | 12 (8, 14) | 12 (9, 14) | 13 (9, 14) | 0.29 |
 SOFA | 4 (2, 6) | 4 (3, 6) | 4 (2, 6) | 4 (2, 6) | 0.142 |
 SAPS-II | 31 (24, 39) | 33 (26, 39) | 33 (26, 40) | 28 (21, 36) | < 0.001 |
 OASIS | 32 (26, 38) | 33 (27.5, 39) | 33 (27, 38) | 31 (25, 36) | < 0.001 |
Comorbidities | |||||
 IVH | 131 (15.0) | 49 (17.1) | 44 (15) | 38 (13) | 0.384 |
 Hypertension | 158 (18.1) | 48 (16.7) | 62 (21.2) | 48 (16.4) | 0.246 |
 Diabetes | 250 (28.6) | 71 (24.7) | 96 (32.8) | 83 (28.3) | 0.101 |
 COPD | 94 (10.8) | 37 (12.9) | 28 (9.6) | 29 (9.9) | 0.363 |
 Myocardial infarct | 92 (10.5) | 32 (11.1) | 26 (8.9) | 34 (11.6) | 0.515 |
 CHF | 143 (16.4) | 59 (20.6) | 43 (14.7) | 41 (14) | 0.064 |
 PVD | 54 (6.2) | 16 (5.6) | 21 (7.2) | 17 (5.8) | 0.689 |
 Renal failure | 125 (14.3) | 38 (13.2) | 46 (15.7) | 41 (14) | 0.686 |
 Hepatic disorders | 10 (1.1) | 1 (0.3) | 5 (1.7) | 4 (1.4) | 0.357 |
 Sepsis | 292 (33.4) | 104 (36.2) | 86 (29.4) | 102 (34.8) | 0.178 |
Laboratory tests | |||||
 WBC, 109/L | 9.0 (7.1, 11.4) | 8.7 (6.8, 11.2) | 8.6 (7.0, 11.0) | 9.2 (7.5, 11.8) | 0.041 |
 Hb, g/L | 12.2 ± 1.9 | 11.8 ± 1.9 | 12.1 ± 1.9 | 12.7 ± 1.9 | < 0.001 |
 Hematocrit, vol% | 37.0 ± 5.5 | 35.8 ± 5.4 | 36.6 ± 5.4 | 38.5 ± 5.4 | < 0.001 |
 Platelets, 109/L | 201 (161, 250) | 183 (150, 238.5) | 201 (162, 243) | 211 (174, 259) | < 0.001 |
 Glucose, mg/dL | 139.8 ± 61.2 | 137.7 ± 53.5 | 139.7 ± 66.7 | 142.0 ± 62.7 | 0.7 |
 Sodium, mmol/L | 138.2 ± 4.0 | 137.8 ± 4.0 | 138.4 ± 4.0 | 138.5 ± 4.0 | 0.049 |
 Potassium, mmol/L | 3.8 (3.5, 4.1) | 3.8 (3.5, 4.1) | 3.8 (3.5, 4.1) | 3.8 (3.5, 4.1) | 0.834 |
 Serum creatinine, mg/dL | 0.9 (0.7, 1.1) | 0.8 (0.6, 1.0) | 0.8 (0.7, 1.0) | 0.9 (0.7, 1.1) | 0.003 |
 Urea nitrogen, mg/dL | 15 (11, 20) | 15 (11, 20) | 15 (11, 20) | 15 (11, 21) | 0.909 |
 PT, s | 12.2 (11.3, 13.2) | 12.2 (11.3, 13.3) | 12.1 (11.3, 13.1) | 12.2 (11.4, 13.1) | 0.631 |
 APTT, s | 27.3 (24.8, 30.0) | 27.4 (25.2, 30.2) | 27.1 (24.3, 29.8) | 27.3 (24.9, 30.1) | 0.501 |
Treatments | |||||
 Cerebral surgery | 94 (10.8) | 28 (9.8) | 28 (9.6) | 38 (13) | 0.328 |
 Mechanical ventilation | 352 (40.3) | 130 (45.3) | 116 (39.6) | 106 (36.2) | 0.078 |
 Statins | 307 (35.4) | 86 (30.4) | 101 (34.6) | 120 (41.1) | 0.026 |
 Vasopressor | 225 (25.8) | 94 (32.8) | 73 (24.9) | 58 (19.8) | 0.002 |