Table 3 Mediation analyses of TyG, TG, and RC for independent variable hypothyroidism
From: Associations between indicators of lipid and glucose metabolism and hypothyroidism
Implicit variable | Mediator | Total effect | Indirect effect | Direct effect | Proportion mediated, % (95% CI) | |||
|---|---|---|---|---|---|---|---|---|
Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | Coefficient (95% CI) | P value | |||
Cardiovascular disease | TyG | 0.063 (0.031, 0.105) | < 0.001 | 0.011 (0.007, 0.016) | < 0.001 | 0.052 (0.019, 0.093) | < 0.001 | 17.2 (9.0, 39.2) |
TG | 0.062 (0.030, 0.104) | < 0.001 | 0.006 (0.003, 0.011) | < 0.001 | 0.056 (0.023, 0.099) | < 0.001 | 10.0 (4.3, 22.4) | |
RC | 0.062 (0.030, 0.104) | < 0.001 | 0.006 (0.003, 0.011) | < 0.001 | 0.056 (0.023, 0.099) | < 0.001 | 9.9 (4.2, 22.0) | |
Hypertension | TyG | 0.165 (0.105, 0.216) | < 0.001 | 0.032 (0.021, 0.045) | < 0.001 | 0.132 (0.078, 0.181) | < 0.001 | 19.6 (13.3, 30.3) |
TG | 0.165 (0.105, 0.217) | < 0.001 | 0.020 (0.012, 0.031) | < 0.001 | 0.145 (0.087, 0.195) | < 0.001 | 12.0 (7.3, 20.9) | |
RC | 0.165 (0.105, 0.217) | < 0.001 | 0.020 (0.012, 0.031) | < 0.001 | 0.145 (0.087, 0.196) | < 0.001 | 11.9 (7.2, 20.8) | |
Diabetes mellitus | TyG | 0.070 (0.027, 0.118) | < 0.001 | 0.040 (0.028, 0.057) | < 0.001 | 0.030 (-0.009, 0.072) | 0.120 | 57.1 (35.7, 130.9) |
TG | 0.064 (0.019, 0.115) | < 0.001 | 0.017 (0.010, 0.025) | < 0.001 | 0.048 (0.003, 0.098) | 0.040 | 26.0 (13.2, 83.8) | |
RC | 0.064 (0.019, 0.115) | < 0.001 | 0.017 (0.010, 0.025) | < 0.001 | 0.048 (0.003, 0.098) | 0.040 | 25.7 (13.1, 82.9) | |