Table 1 Demographic and medical details of the study participants

Unweighted number

3254

280

2974

Weighted number

279,259,824

25,306,247

253,953,577

Gender

< 0.001¹

 Male

47.49%

24.89%

49.74%

Age

44 ± 16

52 ± 18

43 ± 15

< 0.001²

Race

< 0.001¹

 Mexican American

8.81%

3.94%

9.29%

 Non-Hispanic White

67.61%

84.35%

65.95%

 Non-Hispanic Black

11.41%

5.26%

12.03%

 Other Race

12.16%

6.44%

12.73%

Educational level

0.243¹

 Below high school

18.31%

14.53%

18.69%

 High school degree or comparable

21.83%

20.04%

22.00%

 Some college or associate’s degree

29.70%

28.04%

29.86%

 Beyond college

30.17%

37.40%

29.45%

Marital Status

0.616¹

 Married

53.74%

55.55%

53.56%

PIR

2.73 (1.55, 4.83)

2.92 (1.62, 5.00)

2.73 (1.55, 4.80)

0.312³

BMI (kg/m²)

27.10 (23.72, 31.51)

27.81 (24.15, 32.30)

27.07 (23.70, 31.44)

0.123³

Hypertension

0.004¹

28.12%

41.52%

26.79%

Diabetes mellitus

0.014¹

7.68%

12.39%

7.22%

Cardiovascular disease

0.017¹

4.08%

7.80%

3.71%

Alcohol consumption

0.168¹

79.35%

75.24%

79.76%

Smoking status

0.079¹

43.57%

38.35%

44.08%

FPG (mg/dL)

99 (92, 106)

98 (92, 106)

99 (92, 106)

0.443³

FT3 (pg/mL)

3.20 (3.00, 3.50)

3.01 (2.80, 3.30)

3.22 (3.00, 3.50)

< 0.001³

FT4 (pmol/L)

0.80 (0.70, 0.90)

0.80 (0.70, 0.90)

0.80 (0.70, 0.89)

0.035³

TSH (mIU/L)

1.65 (1.13, 2.44)

4.62 (2.12, 5.68)

1.58 (1.12, 2.27)

< 0.001³

TGAb (IU/mL)

0.60 (0.60, 0.60)

0.60 (0.60, 4.30)

0.60 (0.60, 0.60)

< 0.001³

TPOAb (IU/mL)

0.70 (0.30, 1.80)

2.79 (0.60, 72.62)

0.60 (0.30, 1.50)

< 0.001³

TG (mg/dL)

104 (74, 148)

121 (88, 160)

103 (73, 147)

< 0.001³

TC (mg/dL)

194 (171, 222)

200 (178, 227)

194 (170, 221)

0.015³

LDL-C (mg/dL)

117 (96, 140)

119 (99, 141)

117 (96, 140)

0.247³

HDL-C (mg/dL)

52 (43, 63)

56 (45, 67)

52 (43, 62)

0.033³

non-HDL-C (mg/dL)

141 (116, 167)

148 (123, 173)

140 (116, 166)

0.041³

RC (mg/dL)

21 (15, 30)

24 (18, 32)

21 (15, 29)

< 0.001³

LDL/HDL-C

2.25 (1.67, 2.95)

2.20 (1.75, 3.02)

2.26 (1.67, 2.95)

0.797³

TG/HDL-C

1.99 (1.24, 3.30)

2.12 (1.37, 3.50)

1.98 (1.22, 3.28)

0.137³

NHHR

2.72 (1.97, 3.60)

2.65 (2.01, 3.90)

2.73 (1.96, 3.59)

0.873³

TC/HDL-C

3.72 (2.97, 4.60)

3.65 (3.01, 4.90)

3.73 (2.96, 4.59)

0.873³

RC/HDL-C

0.40 (0.25, 0.66)

0.43 (0.27, 0.70)

0.40 (0.25, 0.66)

0.142³

METS-IR

39.76 (33.00, 47.74)

41.24 (33.04, 49.82)

39.67 (33.00, 47.49)

0.325³

TyG

8.56 ± 0.58

8.70 ± 0.54

8.55 ± 0.59

< 0.001²

AIP

0.30 ± 0.30

0.34 ± 0.30

0.30 ± 0.30

0.097²