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Table 3 Cox regression univariate and multivariate analysis for cardiovascular mortality including SUA/GFR ratio and TG/HDL-C quintiles

From: Predictive value of TG/HDL-C and GFR-adjusted uric acid levels on cardiovascular mortality: the URRAH study

 

UNIVARIATE ANALYSIS

MULTIVARIATE ANALYSIS (MODEL 1)

MULTIVARIATE ANALYSIS (MODEL 2)

 

HR

95% CI

P value

HR

95% CI

P value

HR

95% CI

P value

Age, years

1.12

1.11–1.12

 < 0.0001

1.11

1.10 – 1.11

< 0.0001

1.30

1.17 – 1.45

< 0.0001

Gender, male

1.02

0.91–1.13

0.767

1.30

1.17 – 1.45

< 0.0001

1.11

1.10 – 1.11

< 0.0001

BMI, Kg/m2

1.01

1.00–1.03

0.025

0.98

0.96 – 0.99

0.001

0.98

0.96 – 0.99

< 0.0001

SUA/GFR, (logarithm)

3.74

3.36–4.15

 < 0.0001

1.51

1.32 – 1.71

< 0.0001

1.52

1.33 – 1.73

< 0.0001

Diabetes (the presence of)

3.81

3.37–4.30

 < 0.0001

1.99

1.75 – 2.27

< 0.0001

1.79

1.63 – 1.97

< 0.0001

Hypertension (the presence of)

2.28

2.00–2.61

 < 0.0001

1.09

0.95– 1.25

0.213

1.09

0.95– 1.25

0.123

Statins, treatment

0.50

0.35–0.73

 < 0.0001

0.23

0.16 – 0.33

< 0.0001

0.23

0.16 – 0.33

< 0.0001

TG/HDL-C (logarithm)

      

1.15

1.05 – 1.26

0.027

TG/HDL-C

(1° quintile)

REF

  

REF

     

TG/HDL-C

(2° quintile)

1.45

1.21–1.75

 < 0.0001

1.13

0.93–1.37

0.204

   

TG/HDL-C

(3° quintile)

1.51

1.26–1.82

 < 0.0001

1.15

0.95–1.39

0.148

   

TG/HDL-C

(4° quintile)

1.71

1.43–2.05

 < 0.0001

1.20

1.00–1.45

0.050

   

TG/HDL-C

(5° quintile)

1.79

1.50–2.14

 < 0.0001

1.37

1.13–1.65

0.001

   
  1. Model 1 includes TG/HDL-C ratio quintiles, Model 2 includes TG/HDL-C expressed as continuous variable
  2. Abbreviations: BMI body mass index, CI confidence interval, GFR glomerular filtration rate, HDL-C high-density lipoprotein cholesterol, HR hazard ratio, TG triglycerides, SUA serum uric acid