Table 1 Demographic and clinical characteristics in patients on the basis of TG/HDL-C quintiles

N

18,694

3778

3728

3676

3649

3863

Age, years

57 ± 15

54.3 ± 16.1

57.9 ± 15.5

58.6 ± 14.9

59.2 ± 14.0

58.3 ± 13.5

< 0.0001

Male gender, %

46.7

40

45.4

48.2

47.8

52.1

< 0.0001

BMI, kg/m2

26.7 ± 4.3

24.6 ± 4.0

26.0 ± 4.2

26.7 ± 4.2

27.6 ± 4.2

28.4 ± 4.1

0.021

Smoke, %

24.1

17.4

21.2

22.2

24.9

29.6

< 0.0001

Exercise, %

55.4

45.1

45.3

41.1

41

39.2

< 0.0001

Hypertension, %

67.2

56.9

66.4

67.7

72.1

72.4

 < 0.0001

SBP, mmHg

143.4 ± 23.7

138.2 ± 24.1

143.6 ± 24.4

144.2 ± 23.7

146.2 ± 23.4

145.6 ± 23.0

0.004

DBP, mmHg,

85.3 ± 12.8

83.0 ± 12.6

84.9 ± 12.7

85.1 ± 12.7

85.9 ± 13.2

86.5 ± 12.9

0.046

HR, bpm

71.9 ± 12.3

71.4 ± 11.8

72.6 ± 12.8

72.2 ± 12.4

72.4 ± 11.7

72.8 ± 12.2

< 0.0001

Creatinine, mg/dl

0.93 ± 0.26

0.85 ± 0.21

0.90 ± 0.20

0.92 ± 0.23

0.95 ± 0.22

0.98 ± 0.28

< 0.0001

GFR, ml/min per 1,73m²

82.1 ± 19.6

89.0 ± 19.5

83.4 ± 19.7

81.5 ± 19.2

79.1 ± 19.2

78.0 ± 19.5

< 0.0001

Uric acid, mg/dl

5.03 ± 1.42

4.37 ± 1.20

4.72 ± 1.35

4.93 ± 1.31

5.25 ± 1.35

5.67 ± 1.48

< 0.0001

Gout, %

1.06

0.13

0.59

0.73

1.55

2.3

< 0.0001

Allopurinol use, %

1.47

0.41

0.69

1.32

1.85

2.41

< 0.0001

Glucose, mg/dl

98.6 ± 25.2

91.7 ± 16.9

95.8 ± 20.9

98.2 ± 23.7

101.2 ± 27.4

106.1 ± 32.9

< 0.0001

Diabetes, %

10.5

5.1

7.1

8.8

11.8

15

< 0.0001

Total Cholesterol, mg/dl

212.2 ± 39.4

201.4 ± 37.6

207.3 ± 38.6

212.6 ± 39.3

217.8 ± 38.5

222.9 ± 39.5

0.043

HDL-cholesterol, mg/dl

52.9 ± 14.9

68.3 ± 14.1

58.3 ± 11.8

51.9 ± 10.6

46.8 ± 9.1

39.2 ± 8.8

< 0.0001

LDL-cholesterol, mg/dl

134.4 ± 35.9

120.8 ± 33.3

131.8 ± 34.1

139.1 ± 34.9

143.3 ± 34.8

137.7 ± 37.8

< 0.0001

Triglycerides, mg/dl

128.7 ± 78.8

62.2 ± 15.7

87.2 ± 18.6

109.2 ± 23.0

140.8 ± 23.3

234.2 ± 100.2

< 0.0001

Triglycerides/HDL-C ratio

2.77 ± 2.37

0.92 ± 0.21

1.50 ± 0.16

2.11 ± 0.20

3.02 ± 0.35

6.20 ± 3.13

< 0.0001

SUA/GFR ratio

0.067 ± 0.038

0.053 ± 0.027

0.062 ± 0.033

0.067 ± 0.035

0.073 ± 0.036

0.080 ± 0.048

< 0.0001

IMT, mm

1.21 ± 0.72

1.08 ± 0.61

1.07 ± 0.55

1.26 ± 0.82

1.34 ± 0.83

1.40 ± 0.79

< 0.0001

Diuretics, %

16.5

10.5

14.3

15.7

19.8

20.6

< 0.0001

Statins, %

5.3

3.6

5.2

5.8

6.3

5.5

 < 0.0001

RAAS inhibitors, %

1.6

1.1

1.5

1.2

1.7

1.5

0.28