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Fig. 4 | Lipids in Health and Disease

Fig. 4

From: SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase

Fig. 4

Compound 3K enhanced the anti-tumor activity of OXA and induced cell apoptosis by inhibiting PKM2 and FASN. CCK8 analysis confirmed that compound 3K inhibited cell viability of T24 cells and 5637 cells (A, B, and C). Compound 3K, OXA, and combination therapy treated T24 cells (D) and 5637 cells (D). Compound 3K decreased the accumulation of PKM2 and Bcl-2 and increased the expression of Bax and Cleaved Caspase-3. Quantitative analysis of the PKM2, FASN, Bax, Bcl-2, and Cleaved Caspase-3 proteins (E). 3K: compound 3K; *P<0.05

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Lipids in Health and Disease

ISSN: 1476-511X