Fig. 2
From: Targeting lipid metabolism: novel insights and therapeutic advances in pancreatic cancer treatment
Role of lipids and fatty acid metabolism in cancer development. Elevated levels of cellular FAs and cholesterol are associated with enhanced cancer progression. Increased FA and cholesterol metabolism drive tumor growth and contribute to reduced efficacy of therapeutic drugs [54]. This metabolic dysregulation also exacerbates the immunosuppressive functions of myeloid cells, potentially impairing T-cell function [143, 144]. The impact of elevated lipid metabolism on immune responses and drug efficacy underscores the critical need to target lipid metabolic pathways to combat chemoresistance. Cancer treatments aim to overcome resistance and improve therapeutic outcomes by inhibiting FA and cholesterol metabolism