Table 4 Multivariate associations of the FTO rs1121980 with the risk of CAD or MI by further stratification analysis
Variable | Allele | Controls | Cases | OR (95% CI) | P vs. controls | |||
|---|---|---|---|---|---|---|---|---|
Number (%) | CAD (%) | MI (%) | CAD | MI | CAD | MI | ||
Age a | Â | Â | Â | Â | Â | Â | Â | |
 ≤ 60 | G | 483 (84.7) | 412 (79.2) | 412 (79.2) | 1.00 | 1.00 | - | - |
A | 87 (15.3) | 108 (20.8) | 108 (20.8) | 1.55 (1.07–2.24) | 1.76 (1.14–2.73) | 0.020e | 0.011 | |
 > 60 | G | 683 (82.1) | 736 (81.4) | 294 (77.0) | 1.00 | 1.00 | - | - |
A | 149 (17.9) | 168 (18.6) | 88 (23.0) | 1.12 (0.85–1.49) | 1.42 (1.00-2.02) | 0.417 | 0.049 | |
Gender b | Â | Â | Â | Â | Â | Â | Â | |
 Male | G | 677 (82.6) | 807 (81.5) | 423 (78.9) | 1.00 | 1.00 | - | - |
A | 143 (17.4) | 183 (18.5) | 113 (21.1) | 1.16 (0.87–1.55) | 1.39 (0.99–1.96) | 0.300 | 0.059 | |
 Female | G | 489 (84.0) | 341 (78.6) | 115 (71.0) | 1.00 | 1.00 | - | - |
A | 93 (16.7) | 93 (21.4) | 47 (29.0) | 1.39 (0.97-2.00) | 1.90 (1.21-3.00) | 0.069 | 0.006 | |
Smoking c | Â | Â | Â | Â | Â | Â | Â | |
 Yes | G | 220 (81.5) | 539 (81.7) | 297 (78.6) | 1.00 | 1.00 | - | - |
A | 50 (18.5) | 121 (18.3) | 81 (21.4) | 1.02 (0.67–1.54) | 1.22 (0.78–1.93) | 0.935 | 0.381 | |
 No | G | 945 (83.6) | 609 (79.7) | 241 (75.3) | 1.00 | 1.00 | - | - |
A | 185 (16.4) | 155 (20.3) | 79 (24.7) | 1.38 (1.06–1.79) | 1.74 (1.24–2.45) | 0.018 | 0.001 | |
Drinking d | Â | Â | Â | Â | Â | Â | Â | |
 Yes | G | 94 (82.5) | 221 (82.5) | 115 (78.8) | 1.00 | 1.00 | - | - |
A | 20 (17.5) | 47 (17.5) | 31 (21.2) | 0.78 (0.36–1.66) | 1.01 (0.45–2.28) | 0.515 | 0.975 | |
 No | G | 1071 (83.3) | 927 (80.2) | 423 (76.6) | 1.00 | 1.00 | - | - |
A | 215 (16.7) | 229 (19.8) | 129 (23.4) | 1.30 (1.03–1.64) | 1.59 (1.19–2.13) | 0.030 | 0.002 | |