FTO rs1121980 polymorphism contributes to coronary artery disease susceptibility in a Chinese Han population

Table 1 The characteristics of CAD, MI and controls

Variable	Controls (n = 701)	CAD (n = 712)	MI (n = 349)	P^a vs. controls
Variable	Controls (n = 701)	CAD (n = 712)	MI (n = 349)	CAD	MI
Age (years)	63.00 (55.00–73.00)	65.00 (56.00–73.00)	62.0 (53.50–71.0)	0.290	0.038^b
Sex (male)	410 (58.5%)	495 (69.5%)	268 (76.8%)	< 0.001	< 0.001
Smoking	135 (19.3%)	330 (46.3%)	189 (54.2%)	< 0.001	< 0.001
Drinking	57 (8.1%)	134 (18.8%)	73 (20.9%)	< 0.001	< 0.001
Hypertension	264 (37.7%)	457 (64.2%)	209 (59.9%)	< 0.001	< 0.001
Diabetes	111 (15.8%)	349 (49.0%)	180 (51.6%)	< 0.001	< 0.001
Dyslipidemia	254 (36.2%)	452 (63.5%)	229 (65.6%)	< 0.001	< 0.001
SBP (mm Hg)	132.00 (120.00-145.00)	138.00 (126.00-155.00)	136.00 (125.00-153.00)	< 0.001	< 0.001
DBP (mm Hg)	73.00 (66.00–80.00)	76.00 (70.00–83.00)	74.00 (68.00–80.00)	< 0.001	0.397
FPG (mM)	5.35 (4.85–6.27)	6.22 (5.20–7.58)	6.23 (5.20–7.57)	< 0.001	< 0.001
TG (mM)	1.30 (0.97–1.75)	1.77 (1.18–2.45)	1.77 (1.23–2.44)	< 0.001	< 0.001
TC (mM)	4.76 (3.96–5.45)	4.77 (3.82–5.67)	4.77 (3.90–5.59)	0.952	0.927
HDL-C (mM)	1.30 (1.05–1.57)	1.15 (0.96–1.39)	1.10 (0.93–1.37)	< 0.001	< 0.001
LDL-C (mM)	2.62 (2.07–3.29)	2.91 (2.11–3.54)	2.82 (2.12–3.63)	0.003	0.009

SBP, systolic blood pressure; DBP, diastolic blood pressure; FPG, fasting plasma glucose; TG, triglyceride; TC, total cholesterol; HDL-C, high density lipoprotein cholesterol; LDL-C, low density lipoprotein cholesterol
Data were presented as number (percentage) or median (interquartile range)
^aP values obtained in the comparison between CAD or MI patients and controls. MI was a subgroup of CAD. The differences between the two groups were determined by the χ² test or the Wilcoxon-Mann-Whitney test
^bP values under 0.05 were indicated in bold font

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