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Table 2 Study population characteristics; individuals aged 6–8 years at baseline and ≥ 18 years at follow-up (N = 692)

From: Tracking of serum lipids from prepuberty to young adulthood: results from the KiGGS cohort study

% or Mean (95%-CI)

Baseline (2003–2006)

Follow-up (2014–2017)

 

N = 692 persons

N = 692 persons

Sex (% female)

51.2 (46.3–56.1)

51.2 (46.3–56.1)

Age (years)

8.0 (7.9–8.1)

18.9 (18.8–19.0)

Serum lipids

 Non-HDL-C (mmol/l)

2.79 (2.72–2.87)

3.03 (2.93–3.13)

 TC (mmol/l)

4.33 (4.26–4.41)

4.43 (4.33–4.53)

 HDL-C (mmol/l)

1.54 (1.51–1.57)

1.40 (1.37–1.43)

Serum lipid categories (%)

 Non-HDL-C

acceptable

72.0 (67.4–76.2)

61.4 (56.5–66.1)

borderline

20.7 (17.1–24.8)

22.8 (18.9–27.3)

high

7.2 (5.0–10.5)

15.7 (12.3–19.9)

TC

 acceptable

55.6 (50.9–60.2)

53.7 (48.5–58.7)

 borderline

34.5 (30.2–39.0)

26.1 (22.0–30.7)

 high

9.9 (7.2–13.4)

20.2 (16.7–24.3)

HDL-C (mmol/l)

 acceptable

87.7 (83.8–90.7)

76.0 (71.1–80.3)

 borderline

8.0 (5.5–11.5)

13.3 (10.4–16.8)

 low

4.3 (2.7–6.9)

10.8 (7.8–14.8)

TC > 270mg/dl/6.98mmol/l (familial hypercholesterolemia)

0.4 (0.1–3.1)

1.1 (0.3–3.7)

Obesity and behavioral determinants

BMI z-score

0.06 (-0.05–0.17)

0.05 (-0.08–0.19)

Obesity (%)

6.0 (4.0–8.9)

6.9 (4.7–10.0)

Diabetes mellitus (%)

0

0.3 (0.1–1.2)

HFD index score

0.55 (0.54–0.57)

0.36 (0.35–0.38)

 Physical activity per week (%)

 

n. a

 Low

17.7 (13.7–22.6)

 

 Middle

36.2 (31.3–41.4)

 

 High

46.1 (41.1–51.1)

 

Sports (h/week)

n. a

3.4 (3.1–3.7)

Smoking (%)

n. a

30.8 (26.3–25.7)

Alcohol use (%)

n. a

 

 No

 

19.5 (15.1–24.9)

 Moderate

 

32.6 (27.8–37.8)

 At risk

 

47.9 (43.0–52.9)

Medication use (%)

 Oral contraceptives (among women, N = 343)

0

26.6 (23.0–30.7)

 Lipid lowering-medication use

0

0.4 (0.1–3.0)

 Systemic corticosteroids

0

0.1 (0.0–0.8)

  1. Baseline: Baseline: KiGGS baseline (2003–2006), Follow-up: KiGGS wave 2 (2014–2017)
  2. Cut-points for serum lipids for children and young adults according to Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents [36], see Table 1
  3. HDL-C High density lipoprotein cholesterol, HFD Healthy Food Diversity index, non-HDL-C Non-High-density lipoprotein cholesterol, KIGGS German Health Interview and Examination Survey for Children and Adolescents, TC Total cholesterol
  4. N Missing Baseline: BMI = 2, HFD index = 24, physical activity = 40, diabetes = 7
  5. N Missing Follow-up: BMI = 3, HFD index = 18, sports = 20, smoking = 15, alcohol use = 16, oral contraceptive use = 6, lipid-lowering medication use = 6, systemic corticosteroids = 6, diabetes = 2
  6. N fulfilling exclusion criteria for sensitivity analyses (at baseline): TC > 270mg/dl = 1
  7. N fulfilling exclusion criteria for sensitivity analyses (at follow-up): TC > 270mg/dl = 6, diabetes = 2, oral contraceptive use = 193, lipid-lowering medication = 1, systemic corticosteroids = 1