Mediating role of triglyceride-glucose index and its derivatives in the relationship between central obesity and Hashimoto thyroiditis in type 2 diabetes

Table 2 ROC analysis of IR and obesity indices for predicting HT

Indices	AUC (95% CI)	Cut-off	Sens. (%)	Spec. (%)	Youden Index	P value
Male
BMI	0.518(0.476,0.559)	25.45	54.37	52.56	0.069	0.473
WC	0.615(0.574,0.655)	89.80	71.83	48.84	0.207	< 0.001*
WHtR	0.619(0.578,0.659)	0.53	69.01	55.35	0.244	< 0.001*
WHR	0.651(0.611,0.691)	0.94	63.10	63.72	0.268	< 0.001*
^aLAP	0.530(0.488,0.571)	85.25	20.56	86.51	0.071	0.231
^aVFA	0.526(0.484,0.568)	92.74	58.87	49.77	0.086	0.303
TyG	0.541(0.499,0.583)	9.19	51.55	58.60	0.102	0.095
TyG-BMI	0.532(0.490,0.573)	231.85	48.17	62.79	0.110	0.194
TyG-WC	0.562(0.520,0.603)	882.65	47.89	65.12	0.130	0.012*
TyG-WHtR	0.560(0.518,0.601)	5.18	46.76	66.51	0.133	0.015*
TyG-WHR	0.565(0.523,0.606)	9.50	27.04	85.12	0.122	0.007*
Female
BMI	0.562(0.517,0.606)	24.39	70.82	43.02	0.138	0.025*
WC	0.649(0.605,0.691)	83.30	82.37	41.86	0.242	< 0.001*
WHtR	0.635(0.591,0.677)	0.52	82.37	43.60	0.260	< 0.001*
WHR	0.650(0.607,0.692)	0.91	74.16	52.91	0.271	< 0.001*
^aLAP	0.567(0.523,0.611)	29.76	85.11	29.07	0.142	0.014*
^aVFA	0.569(0.524,0.612)	88.41	79.94	32.56	0.125	0.012*
TyG	0.514(0.470,0.559)	9.83	84.19	22.67	0.069	0.603
^bTyG-BMI	0.544(0.500,0.589)	202.28	88.75	19.77	0.085	0.104
TyG-WC	0.617(0.573,0.660)	804.98	64.13	55.23	0.194	< 0.001*
TyG-WHtR	0.604(0.560,0.647)	4.92	70.82	46.51	0.17	< 0.001*
TyG-WHR	0.600(0.556,0.644)	8.22	71.43	45.93	0.174	< 0.001*

ROC receiver operating characteristic, AUC areas under the ROC curve, CI confidence interval, Sens sensitivity, Spec specificity, BMI body mass index, WC waist circumference, WHtR waist-to-height, WHR waist to hip ratio, LAP lipid accumulation product, VFA visceral fat area, TyG triglyceride glucose index, TyG-BMI TyG × BMI, TyG-WC TyG × WC, TyG-WHR TyG × WHR, TyG-WHtR TyG × WHtR
^aStatistically significant differences were observed between the AUC of obesity-related indicators and LAP, VFA
^bStatistically significant differences were observed between the AUC of the triglyceride-glucose derivative indices and TyG-BMI
(P values for the DeLong test were < 0.05) ^* P < 0.05

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