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Table 3 Multi-adjusted logistic regression models evaluating the association between lipid markers, and 20-year cumulative incidence of T2DM

From: Association between simple, combined lipid markers and 20-year cumulative incidence of type 2 diabetes: the ATTICA cohort study (2002–2022)

Models *

Unadjusted for fasting glucose

Adj. for fasting glucose

Model accuracy

OR

95%CI

OR

95%CI

C-statistic*

Model 1: Total cholesterol (per 1 mg/dL)

1.01

1.01, 1.02

0.99

0.97, 1.02

0.749

Model 2: HDL-C (per 1 mg/dL)

0.98

0.97, 0.99

0.92

0.83, 1.01

0.741

Model 3: LDL-C (per 1 mg/dL)

1.01

1.01, 1.02

1.01

0.99, 1.04

0.750

Model 4: Triglycerides (per 1 mg/dL)

1.01

1.01, 1.02

0.99

0.98, 1.01

0.746

Model 5: Non-HDL cholesterol (per 1 mg/dL)

1.01

1.01, 1.02

1.00

0.97, 1.02

0.745

Model 6: Triglycerides/HDL-C (per 1 unit)

1.11

1.02, 1.20

1.11

0.82, 1.51

0.743

Model 7: Total cholesterol/HDL-C (per 1 unit)

1.22

1.08, 1.37

2.09

0.99, 4.67

0.743

Model 8: LDL-C/HDL-C (per 1 unit)

1.17

1.01, 1.36

2.66

1.01, 2.68

0.750

Model 9: CMI (per 1 unit)

1.21

1.06, 1.39

1.25

0.73, 2.17

0.745

Model 10: NHHR (per 1 unit)

1.22

1.08, 1.37

2.10

1.01, 4.67

0.743

Model 11: TyG (per 1 unit)

3.58

2.51, 5.10

1.27

0.23, 7.02

0.750

Model 12: LAP (per 1 unit)

0.99

0.99, 1.01

0.99

0.98, 1.01

0.714

  1. ORs and their corresponding 95%CIs were obtained through logistic regression analysis, as proxy of Relative Risks. *All the above models were adjusted for: age (years), sex (female vs. male), smoking status (yes vs. no), physical activity level (yes/no), MedDietScore, waist to hip ratio, family history of T2DM (yes/no), and dietary supplements related to lipid metabolism. Fasting glucose levels were added in the previous models. **C-statistic is derived from the age-, sex-adjusted models that included the tested simple and combined lipid markers. Abbreviations OR: Odds Ratio; CI: Confidence Interval; HDL-C: High Density Lipoprotein – Cholesterol; LDL-C: Low Density Lipoprotein – Cholesterol; CMI: TGs/HDL-C*WHtR: TGs: Triglycerides; WHtR: Waist circumference to height ratio; CMI: Cardiometabolic Index; NHHR: Non-HDL-cholesterol to HDL-cholesterol ratio; TyG: Triglycerides-glucose index; LAP: Lipid Accumulation Product
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Lipids in Health and Disease

ISSN: 1476-511X