Fig. 4

Analyses of transcriptomic differences ergothioneine-treated AML12 cells. (A) Principal component analysis (PCA) of RNA-seq in AML12. (B-E) Difference analysis of PA + EGT vs. PA sequencing results. (B) Cluster analysis. (C) Volcano plots. GO (D) and KEGG (E) enrichment analysis. (F-H) Heatmap of GSEA analysis. Heatmap of autophagy (F), apoptosis (G) and oxidative stress (H) related gene expression profiles. C: Ctrl, P: PA, E: PA + EGT, n = 3