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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Ergothioneine ameliorates metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) by enhancing autophagy, inhibiting oxidative damage and inflammation

Fig. 3

Ergothioneine attenuated PA-induced lipid metabolism impairment in AML12. (A) Percentage of AML12 cells viability detected by CCK8. (B) Status of AML12 lipid deposition detected by Oil Red. (C) Percentage of cell viability in AML12 cells intervened by ergothioneine at different concentrations detected by CCK8. (D) Status of AML12 lipid deposition intervened by ergothioneine at different concentrations detected by Oil Red. qPCR detected FASN (E), CPT1α (F), ApoB (G) and PPARα (H) mRNA expression levels in AML12 cells. mM: mmol/L, bar:20 μm, n = 3. * P < 0.05, ** P < 0.01, **** P < 0.0001 PA vs. Ctrl; #P < 0.05. ###P < 0.001, ####P < 0.0001 PA + EGT vs. PA

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Lipids in Health and Disease

ISSN: 1476-511X