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Table 1 Demographic data and serum biochemical parameters of the study groups. Except for the serum cholesterol and creatinine levels, there were no significant differences between the two groups

From: Determination of selected oxysterol levels, oxidative stress, and macrophage activation indicators in children and adolescents with familial hypercholesterolemia

 

FH (n = 20)

HC (n = 20)

P value

Demographic data

   

Age

Mean ± SD

(Min-Max)

12.65 ± 3.60

(6–18)

13.43 ± 3.4

(6–18)

0.4611

Body mass index (BMI) (kg/m2)

Mean ± SD

(Min-Max)

19.40 ± 3.09

(13.264–24.120)

20.98 ± 2.17

(16.188–24.442)

0.1101

Sex ratio (Female/Male)

7/13

8/12

0.999

Serum biochemical parameters

   

Glucose (mg/dL)

Mean ± SD

(Min-Max)

84.4 ± 5.8

(72–92)

86.35 ± 6.59

(75–94)

0.4891

Blood Urea Nitrogen (mg/dL)

Mean ± SD

( 25–75%)

22.10 ± 5.11

(18.25–26.25)

22.85 ± 5.62

(19–26.00)

0.577

Creatinine (mg/dL)

Mean ± SD

(Min-Max)

0.56 ± 0.15

(0.35–0.98)

0.68 ± 0.19

(0.38–0.98)

0.0367 *

AST (U/L)

Mean ± SD

(Min-Max)

19.2 ± 6.1

(8.00–32.00)

19.6 ± 6.2

(10.00–35.00)

0.8564

ALT (U/L)

Mean ± SD

(Min-Max)

18.2 ± 13.6

(8.00–50.00)

15.4 ± 8.2

(8.00–40.00)

0.8352

Total -C (mg/dL)

Mean ± SD

(25–75%)

231.8 ± 49.5

(193.0-270.5)

152.5 ± 24.7

(132.5–168.3)

< 0.0001****

HDL-C (mg/dL)

Mean ± SD

(Min-Max)

46.42 ± 11.94

(28.0–66.0)

56.40 ± 10.45

(38.0–76.0)

0.0153 *

LDL-C (mg/dL)

Mean ± SD

(25–75%)

172.3 ± 50.76

(138.5-206.3)

78.50 ± 21.48

(70.25–94.50)

< 0.0001****

Triglycerides (mg/dL) Mean ± SD

( 25–75%)

75.80 ± 25.88

(57.25–93.25)

72.75 ± 31.29

(53.75-83)

0.507

Total Protein (g/L) Mean ± SD

(Min-Max)

72.62 ± 3.70

(63.5–76.0)

72.14 ± 3.48

(65.0–75.0)

0.657

  1. FH: Familial hypercholesterolemia, HC: Healthy Control