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Fig. 7 | Lipids in Health and Disease

Fig. 7

From: Deficiency of lysophosphatidic acid receptor 3 decreases erythropoietin production in hypoxic mouse kidneys

Fig. 7

LPAR3 regulates EPO induction by hypoxia. In hypoxic cells, LPAR3 is activated by LPA or its agonist OMPT, resulting in PI3K-Akt pathway activation, which contributes to the stabilization of HIF-2α. The stabilized HIF-2α subsequently translocates into the nucleus and forms a heterodimer with HIF-β to bind with the HRE (HIF-responsive element) in the Epo promoter for transcriptional activation of the Epo gene. The induction of EPO by hypoxia is suppressed by treatment with the LPAR1/3 inhibitor Ki16425 or LY294002, a pan-PI3K inhibitor

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Lipids in Health and Disease

ISSN: 1476-511X