Fig. 5

Mediation effects of AIP, TyG, and RC in the association of CRS with depression
Caption: ACME, average causal mediation effects (indirect effect); ADE, average direct effects; Dep: depression. * P < 0.05, ** P < 0.01, and *** P < 0.001. The model adjusted for age, gender, race, education level, marital status, PIR, drinking, smoking, diabetes, hypertension, BMI, PA, HDL-C, LDL-C, TG, FPG, HbA1c, UA, BUN, eGFR, UACR, antihyperglycemic drugs, antihypertensive drug, antithrombotic drugs, lipid-lowering drugs, and antidepressant drugs