Table 1 Detailed description of human blood metabolites GWASs
Reference | phenotype | Study Cohort | Cohort design | GWAS Sample Size | Population | Female% | Mean Age | Sample material |
|---|---|---|---|---|---|---|---|---|
Shin et al. [24] | 453 Metabolites | TwinsUK | An adult twin British registry cohort study | 6056 | German | 93 | 53.4 | 1052 Serum, 5004 Plasma |
KORA | Population-based cohort study | 1768 | British | 52 | 60.8 | Serum | ||
Kettunen et al. [25] | 123 Metabolites | EGCUT | Population-based cohort study | 3,287 | Estonian | 58 | 46.3 | Plasma |
COROGENE | Case-control study, only controls uesd | 828 | Finnish | 54 | 53.2 | Serum | ||
FR97 | Population-based cohort study | 3,661 | Finish | 45.3 | 55 | Serum | ||
ERF | Family-based study | 2,118 | Dutch | 58 | 48.2 | Serum | ||
HBCS | British cohort study | 708 | Finnish | 60 | 61.3 | Serum | ||
GenMets | Case-control study | 572 | Finnish | 57 | 55.8 | Serum | ||
LLS | Family-based study | 2,227 | Dutch | 54 | 59.2 | Plasma | ||
KORA | Population based cohort study | 1,745 | German | 52 | 60.9 | Serum | ||
NTR | Population based twin study | 1,192 | Dutch | 64 | 38.8 | Plasma | ||
NFBC 1966 | Brith cohort study | 4,709 | Finnish | 51 | 31.2 | Serum | ||
PROTE | Population based study | 597 | Estonian | 51 | 38.3 | Plasma | ||
Predict CVD | Cohort study | 374 | Finnish | 37 | 47.5 | Serum | ||
YFS | Follow up study in children | 2,390 | Finnish | 54 | 37.7 | Serum | ||
FTC | Population based twin study | 664 | Finnish | 50 | 23.9 | Serum | ||
Borges et al. | 249 Metabolites | UK Biobank | Population-based study | 115,078 | European | NA | NA | Blood |
Total | 825 Metabolites | / | / | 147,827 | European | / | / | Blood |