Table 2 Baseline clinical characteristics of patients stratified by the AIP and GA
Variables | AIP-L + GA-L (n = 324) | AIP-H + GA-L (n = 329) | AIP-L + GA-H (n = 335) | AIP-H + GA-H (n = 317) | P value |
|---|---|---|---|---|---|
Demographics | |||||
Age, years | 65.02 ± 7.71 | 63.84 ± 7.15 | 65.85 ± 7.08 | 64.99 ± 7.07 | 0.005 |
BMI, kg/m2 | 25.25 ± 3.51 | 25.78 ± 3.15 | 25.01 ± 3.38 | 25.73 ± 3.09 | 0.007 |
SBP, mmHg | 132.11 ± 17.82 | 131.53 ± 17.49 | 134.49 ± 18.01 | 134.23 ± 17.56 | 0.080 |
DBP, mmHg | 74.86 ± 11.40 | 75.99 ± 10.45 | 73.90 ± 10.08 | 75.16 ± 10.76 | 0.098 |
Current smoking, n (%) | 10 (3.1) | 14 (4.2) | 9 (2.7) | 13 (4.1) | 0.678 |
Previous smoking, n (%) | 2 (0.6) | 5 (1.5) | 4 (1.2) | 10 (3.2) | 0.067 |
Current drinking, n (%) | 6 (1.9) | 3 (0.9) | 2 (0.6) | 3 (0.9) | 0.445 |
Previous drinking, n (%) | 0 (0.0) | 1 (0.3) | 0 (0.0) | 2 (0.6) | 0.284 |
Family history of CVD, n (%) | 22 (6.8) | 21 (6.3) | 23 (7.0) | 28 (8.8) | 0.614 |
Medical histories, n (%) | |||||
Hypertension | 215 (66.4) | 238 (71.0) | 232 (70.5) | 230 (72.6) | 0.355 |
Hyperlipemia | 219 (67.6) | 233 (69.6) | 216 (65.7) | 244 (77.0) | 0.011 |
T2DM | 22 (6.8) | 23 (6.9) | 206 (62.6) | 204 (64.4) | < 0.001 |
Previous MI | 25 (7.7) | 24 (7.2) | 22 (6.7) | 38 (12.0) | 0.059 |
Previous PCI | 58 (17.9) | 55 (16.4) | 90 (27.4) | 90 (28.4) | < 0.001 |
Previous stroke | 14 (4.3) | 15 (4.5) | 15 (4.6) | 21 (6.6) | 0.492 |
Laboratory results | |||||
TG, mmol/L | 1.07 [0.88, 1.27] | 1.97 [1.63, 2.54] | 1.01 [0.79, 1.19] | 1.91 [1.61, 2.64] | < 0.001 |
TC, mmol/L | 4.24 [3.65, 4.90] | 4.41 [3.79, 5.14] | 4.07 [3.53, 4.83] | 4.39 [3.76, 5.12] | < 0.001 |
HDL-C, mmol/L | 1.32 [1.16, 1.50] | 1.06 [0.94, 1.20] | 1.28 [1.15, 1.49] | 1.05 [0.91, 1.17] | < 0.001 |
LDL-C, mmol/L | 2.44 [1.88, 3.12] | 2.59 [2.04, 3.15] | 2.29 [1.86, 2.95] | 2.51 [1.95, 3.09] | 0.003 |
LVEF, % | 65.00 [62.00, 69.00] | 65.00 [60.00, 68.00] | 65.00 [60.00, 68.00] | 65.00 [60.00, 67.00] | 0.011 |
eGFR, mL/min/1.73 m2 | 94.11 [87.48, 99.74] | 92.44 [84.65, 98.21] | 91.55 [83.67, 98.17] | 90.74 [78.79, 96.95] | < 0.001 |
Cr, mmol/L | 55.80 [49.38, 62.32] | 57.70 [50.95, 65.70] | 57.40 [50.40, 65.60] | 59.50 [53.20, 68.00] | < 0.001 |
AIP | -0.08 [-0.19, 0.02] | 0.25 [0.16, 0.38] | -0.10 [-0.22, -0.01] | 0.25 [0.15, 0.41] | < 0.001 |
GA, % | 14.30 [13.50, 14.80] | 13.90 [13.20, 14.50] | 18.00 [16.20, 21.20] | 18.00 [16.30, 21.50] | < 0.001 |
hs-CRP, mg/L | 1.15 [0.49, 2.88] | 1.56 [0.65, 3.79] | 1.23 [0.50, 2.90] | 1.79 [0.76, 3.99] | < 0.001 |
FBG, mmol/L | 5.33 [4.97, 5.82] | 5.38 [5.03, 5.92] | 6.70 [5.52, 8.51] | 7.10 [5.97, 9.27] | < 0.001 |
Uric acid, µmol/L | 286.60 [246.15, 330.35] | 321.60 [281.60, 368.90] | 277.20 [235.30, 333.20] | 317.40 [263.90, 368.10] | < 0.001 |
HbA1c, % | 5.80 [5.50, 6.10] | 5.90 [5.60, 6.20] | 7.00 [6.20, 8.00] | 7.30 [6.50, 8.25] | < 0.001 |
Diagnosis on admission, n (%) | |||||
UAP | 287 (88.6) | 289 (87.8) | 289 (86.3) | 275 (86.8) | 0.808 |
NSTEMI | 14 (4.3) | 19 (5.7) | 24 (7.3) | 24 (7.6) | 0.281 |
STEMI | 23 (7.1) | 27 (8.1) | 16 (4.9) | 18 (5.7) | 0.340 |
Medications, n (%) | |||||
DAPT | 324 (100.0) | 334 (99.7) | 329 (100.0) | 317 (100.0) | 0.408 |
Statin | 321 (99.1) | 330 (98.5) | 327 (99.4) | 315 (99.4) | 0.605 |
β-Blocker | 187 (57.7) | 216 (64.5) | 210 (63.8) | 207 (65.3) | 0.173 |
ACEI/ARB | 139 (42.9) | 159 (47.5) | 149 (45.3) | 165 (52.1) | 0.120 |
CCB | 100 (30.9) | 131 (39.1) | 126 (38.3) | 126 (39.7) | 0.068 |
Antidiabetic drugs | |||||
Insulin | 8 (2.5) | 5 (1.5) | 61 (18.5) | 57 (18.0) | < 0.001 |
OAD | 18 (5.6) | 16 (4.8) | 137 (41.6) | 131 (41.3) | < 0.001 |
Angiographic data | |||||
LM disease, n (%) | 12 (3.7) | 18 (5.4) | 17 (5.2) | 20 (6.3) | 0.513 |
One-vessel disease, n (%) | 136 (42.0) | 134 (40.0) | 99 (30.1) | 85 (26.8) | < 0.001 |
Two-vessel disease, n (%) | 106 (32.7) | 100 (29.9) | 134 (40.7) | 131 (41.3) | 0.003 |
Three-vessel disease, n (%) | 82 (25.3) | 101 (30.1) | 96 (29.2) | 101 (31.9) | 0.307 |
CTO disease, n (%) | 43 (13.3) | 59 (17.6) | 51 (15.5) | 72 (22.7) | 0.012 |
Diffuse lesion, n (%) | 101 (31.2) | 115 (34.4) | 141 (42.9) | 121 (38.2) | 0.014 |
Bifurcation lesion, n (%) | 28 (8.6) | 36 (10.8) | 27 (8.2) | 28 (8.8) | 0.669 |
ISR disease, n (%) | 16 (4.9) | 22 (6.6) | 30 (9.1) | 26 (8.2) | 0.175 |
SYNTAX score | 10.00 [7.00, 14.25] | 11.00 [7.00, 16.00] | 11.00 [7.00, 16.00] | 11.50 [7.00, 16.00] | 0.250 |
Procedural results | |||||
Target vessel territory, n (%) | |||||
LM | 10 (3.1) | 8 (2.4) | 8 (2.4) | 10 (3.2) | 0.892 |
LAD | 181 (55.9) | 154 (46.8) | 170 (50.7) | 166 (52.4) | 0.136 |
LCX | 58 (17.9) | 68 (20.7) | 54 (16.1) | 54 (17.0) | 0.458 |
RCA | 91 (28.1) | 111 (33.7) | 118 (35.2) | 103 (32.5) | 0.237 |
DES implantation, n (%) | 315 (97.2) | 319 (97.0) | 323 (96.4) | 305 (96.2) | 0.881 |
DCB use, n (%) | 11 (3.4) | 13 (3.9) | 13 (4.0) | 18 (5.7) | 0.499 |
IABP, n (%) | 3 (0.9) | 0 (0.0) | 5 (1.5) | 1 (0.3) | 0.088 |
IVUS, n (%) | 0 (0.0) | 1 (0.3) | 3 (0.9) | 4 (1.3) | 0.157 |
OCT, n (%) | 3 (0.9) | 3 (0.9) | 2 (0.6) | 1 (0.3) | 0.765 |
Complete revascularization, n (%) | 146 (45.1) | 140 (41.8) | 105 (31.9) | 112 (35.3) | 0.002 |
Number of stents | 1.00 [1.00, 2.00] | 1.00 [1.00, 2.00] | 1.00 [1.00, 2.00] | 1.00 [1.00, 2.00] | 0.988 |
Diameter of stents, mm | 2.75 [2.50, 3.00] | 2.75 [2.50, 3.00] | 2.75 [2.50, 3.00] | 2.75 [2.50, 3.00] | 0.002 |
Length of stents, mm | 23.00 [18.00, 29.00] | 23.00 [16.00, 30.00] | 23.00 [16.00, 30.00] | 22.00 [15.00, 30.00] | 0.892 |