Table 4 Longitudinal and cross-sectional associations of 22 previously known CpGs with LFC in Changfeng population
CpG | Chr | POS | UCSC_ RefGene | Gencode BasicV12 _Group | Relation_ to_Island | Longitudinal | Baseline | Follow-up | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
P†| Effect Direction | P | Effect Direction | P | Effect Direction | ||||||
cg09469355 | 1 | 2,161,886 | SKI | Â | S_Shore | 5.76E-01 | +- | 4.45E-01 | +- | 3.20E-01 | -- |
cg17901584 | 1 | 55,353,706 | DHCR24 | TSS1500; 5’UTR | S_Shore | 5.24E-04 | -- | 7.49E-03 | -- | 7.75E-03 | -- |
cg03725309 | 1 | 109,757,585 | SARS | Â | S_Shore | 3.95E-01 | +- | 9.63E-01 | -+ | 5.65E-01 | +- |
cg14476101 | 1 | 120,255,992 | PHGDH | 5’UTR | S_Shore | 5.50E-01 | -+ | 2.02E-01 | -+ | 9.19E-01 | -+ |
cg19693031 | 1 | 145,441,552 | TXNIP | 3’UTR; 5’UTR | OpenSea | 1.45E-04 | -- | 3.16E-02 | -- | 2.44E-03 | -- |
cg06690548 | 4 | 139,162,808 | SLC7A11 | Â | OpenSea | 4.00E-01 | -- | 1.63E-01 | -- | 9.96E-01 | -+ |
cg05119988 | 4 | 166,251,189 | SC4MOL | 5’UTR | S_Shelf | 3.57E-01 | -- | 2.77E-01 | -- | 3.61E-01 | -- |
cg03957124 | 6 | 37,016,869 | Â | Â | S_Shelf | 8.56E-02 | -- | 7.81E-01 | +- | 1.21E-02 | -- |
cg18120259 | 6 | 43,894,639 | Â | Â | OpenSea | 6.05E-02 | -- | 8.78E-02 | -- | 2.77E-01 | -+ |
cg17501210 | 6 | 166,970,252 | RPS6KA2 | 5’UTR | OpenSea | 9.33E-01 | -+ | 2.90E-01 | ++ | 2.46E-01 | -+ |
cg21429551 | 7 | 30,635,762 | GARS | Â | S_Shore | 5.23E-01 | ++ | 8.57E-01 | -+ | 4.18E-01 | ++ |
cg11376147 | 11 | 57,261,198 | SLC43A1 | 3’UTR | OpenSea | 2.15E-01 | -- | 3.05E-01 | -- | 2.07E-01 | -- |
cg00574958 | 11 | 68,607,622 | CPT1A | 5’UTR | N_Shore | 1.66E-06 | -- | 3.36E-02 | -- | 9.14E-06 | -- |
cg26894079 | 11 | 122,954,435 | ASAM | 1stExon; 3’UTR | OpenSea | 9.82E-02 | -- | 3.72E-01 | -- | 8.29E-02 | -- |
cg11024682 | 17 | 17,730,094 | SREBF1 | Â | S_Shelf | 1.61E-12 | ++ | 3.81E-05 | ++ | 4.89E-09 | ++ |
cg14020176 | 17 | 72,764,985 | SLC9A3R1 | 3’UTR | OpenSea | 9.36E-04 | ++ | 5.29E-02 | ++ | 8.95E-03 | ++ |
cg19016694 | 17 | 80,821,826 | TBCD | 3’UTR | S_Shelf | 1.05E-01 | -- | 3.88E-01 | -- | 2.41E-01 | -- |
cg15860624 | 19 | 3,811,194 | ZFR2 | Â | Island | 1.29E-01 | ++ | 5.57E-01 | +- | 3.24E-01 | ++ |
cg08309687 | 21 | 35,320,596 |  | TSS1500; 5’UTR | OpenSea | 1.32E-03 | -- | 1.21E-01 | -+ | 1.29E-03 | -- |
cg27243685 | 21 | 43,642,366 | ABCG1 | 5’UTR | S_Shelf | 1.16E-06 | ++ | 2.00E-03 | +- | 4.94E-05 | ++ |
cg06500161 | 21 | 43,656,587 | ABCG1 | 5’UTR | S_Shore | 5.64E-10 | ++ | 5.39E-03 | ++ | 2.17E-08 | ++ |
cg02711608 | 19 | 47,287,964 | SLC1A5 | 5’UTR;1stExon | N_Shelf | NA | NA | NA | NA | NA | NA |