Table 2 Significant CpGs in longitudinal EWAS and cross-sectional EWAS of LFC
CpG | Chr | POS | UCSC_ RefGene | Gencode BasicV12 _Group | Relation_ to_Island | Discovery | Replication | Meta-analysis | P adjust BMI†| |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Effect | P | Effect | P | P | Effect Direction | |||||||
EWAS-LMM: LFC vs. DNAm | ||||||||||||
cg15659943 | 9 | 107,631,656 | ABCA1 | Body | OpenSea | 4.57E-04 | 1.13E-06 | 4.78E-04 | 2.44E-02 | 8.70E-08 | ++ | 6.89E-07 |
cg00163198 | 11 | 130,767,760 | SNX19 | 3’UTR | OpenSea | 5.01E-04 | 5.73E-07 | 8.94E-04 | 5.26E-05 | 2.61E-10 | ++ | 3.04E-09 |
cg11024682 | 17 | 17,730,094 | SREBF1 | Body | S_Shelf | 6.43E-04 | 1.93E-10 | 6.94E-04 | 2.09E-03 | 1.61E-12 | ++ | 6.65E-09 |
cg16740586 | 21 | 43,655,919 | ABCG1 | 5’UTR | S_Shore | 5.40E-04 | 8.32E-08 | 5.96E-04 | 2.21E-02 | 6.47E-09 | ++ | 7.39E-06 |
cg06500161 | 21 | 43,656,587 | ABCG1 | 5’UTR | S_Shore | 4.82E-04 | 1.39E-08 | 5.17E-04 | 1.11E-02 | 5.64E-10 | ++ | 3.93E-07 |
Longitudinal EWAS: â–³LFC vs. â–³DNAm | ||||||||||||
cg09154567 | 22 | 44,239,861 | SULT4A1 | Body | OpenSea | -7.25E-05 | 5.16E-01 | -1.34E-03 | 7.68E-08 | 2.30E-03 | -- | 2.45E-08 |
Cross-sectional EWAS: LFC vs. DNAm | ||||||||||||
cg11024682 | 17 | 17,730,094 | SREBF1 | Body | S_Shelf | 6.35E-04 | 7.84E-07 | 9.13E-04 | 1.59E-03 | 4.89E-09 | ++ | 1.71E-06 |
cg07162647 | 19 | 40,466,275 | Body | OpenSea | -4.24E-04 | 3.29E-07 | -5.71E-04 | 1.75E-02 | 1.95E-08 | -- | 1.77E-07 | |
cg06500161 | 21 | 43,656,587 | ABCG1 | 5’UTR | S_Shore | 5.65E-04 | 1.05E-07 | 5.05E-04 | 5.05E-02 | 2.17E-08 | ++ | 4.10E-06 |