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Table 1 Characteristics of the study population and comparison between healthy controls, and those with MCI and dementia

From: Sleep and nighttime behavior disorders in older adults: associations with hypercholesterolemia and hypertriglyceridemia at baseline, and a predictive analysis of incident cases at 12 months follow-up

Characteristic

N

Overall,

N = 2,216a

Healthy controls

N = 786a

MCI

N = 1,060a

Dementia

N = 370a

P-value2

Age (years)

2,216

73 (68, 78)

72 (68, 77)

73 (68, 78)

75 (70, 80)

 < 0.001

Sex

2,216

    

 < 0.001

 Female

 

1,045 (47%)

440 (56%)

442 (42%)

163 (44%)

 

 Male

 

1,171 (53%)

346 (44%)

618 (58%)

207 (56%)

 

Educational level (years)

2,216

16.00 (14.00, 18.00)

16.00 (15.00, 18.00)

16.00 (14.00, 18.00)

16.00 (13.00, 18.00)

 < 0.001

Marital status

2,216

    

 < 0.001

 Currently married

 

1,673 (75%)

547 (70%)

815 (77%)

311 (84%)

 

 Currently not married or unknown

 

543 (25%)

239 (30%)

245 (23%)

59 (16%)

 

Home

2,216

    

0.8

 House or appartment

 

2,101 (95%)

748 (95%)

1,006 (95%)

347 (94%)

 

 Retirement or nursing institution

 

76 (3.4%)

26 (3.3%)

34 (3.2%)

16 (4.3%)

 

 Other

 

39 (1.8%)

12 (1.5%)

20 (1.9%)

7 (1.9%)

 

Racial profile

2,216

    

 < 0.001

 White

 

1,952 (88%)

651 (83%)

963 (91%)

338 (91%)

 

 Black

 

167 (7.5%)

92 (12%)

56 (5.3%)

19 (5.1%)

 

 Other

 

97 (4.4%)

43 (5.5%)

41 (3.9%)

13 (3.5%)

 

APOE ε4 status

2,031

    

 < 0.001

 0 allele

 

1,095 (54%)

488 (70%)

495 (50%)

112 (32%)

 

 1 allele

 

735 (36%)

188 (27%)

378 (39%)

169 (48%)

 

 2 alleles

 

201 (9.9%)

22 (3.2%)

108 (11%)

71 (20%)

 

 Missing values

 

185

88

79

18

 

ADAS13 total score

2,216

14 (9, 22)

8 (5, 12)

16 (11, 21)

29 (24, 34)

 < 0.001

MMSE total score

2,216

28.00 (26.00, 29.00)

29.00 (29.00, 30.00)

28.00 (26.00, 29.00)

23.00 (21.00, 25.00)

 < 0.001

CDR-SB

2,216

1.00 (0.00, 2.00)

0.00 (0.00, 0.00)

1.50 (1.00, 2.00)

4.50 (3.50, 5.00)

 < 0.001

FAQ total score

2,211

1.0 (0.0, 5.0)

0.0 (0.0, 0.0)

1.0 (0.0, 5.0)

13.0 (8.0, 18.0)

 < 0.001

 Missing values

 

5

0

4

1

 

GDS total score

2,216

1.00 (0.00, 2.00)

0.00 (0.00, 1.00)

1.00 (1.00, 3.00)

1.00 (1.00, 3.00)

 < 0.001

BMI

2,216

26.3 (23.9, 29.3)

26.7 (24.1, 30.0)

26.3 (24.0, 29.2)

25.4 (23.1, 28.0)

 < 0.001

Cholesterol levels (mg/dL)

2,216

191 (165, 220)

189 (165, 217)

191 (165, 221)

193 (167, 224)

0.4

Triglyceride levels (mg/dL)

2,216

120 (87, 171)

116 (85, 164)

121 (86, 177)

124 (93, 171)

0.078

Sleep disorders at baseline

2,216

357 (16%)

80 (10%)

193 (18%)

84 (23%)

 < 0.001

Sleep disorders at 12 months

1,845

327 (18%)

56 (8.7%)

200 (22%)

71 (23%)

 < 0.001

 Missing values

 

371

141

163

67

 
  1. ADAS13 Alzheimer’s Disease Assessment Score – 13 items, APOE ε4 Apolipoprotein E ε4, BMI Body-Mass Index (Weight in Kg / (Height in m)2), CDR- SB Clinical Dementia Rating Scale—sum of boxes, FAQ Functional Activities Questionnaire, GDS Geriatric Depression Scale, MCI Mild Cognitive Impairment, MMSE Mini-Mental Status Examination
  2. aMedian (IQR); n (%)
  3. 2Kruskal–Wallis rank sum test; Pearson’s Chi-squared test
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Lipids in Health and Disease

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