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Table 1 Enrichment analysis of metabolic pathways of differential metabolites in primary liver cancer

From: Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma

Metabolite set

Total

Hits

Expect

P value

Holm P

FDR

Pathway-related differential metabolites

Total metabolites

Phospholipid biosynthesis

29

2

0.145

0.0077

0.751

0.751

PC(32:0); LysoPE(16:0/0:0)

Choline; Glycerylphosphorylethanolamine; Glycerol 3-phosphate; Ethanolamine; Calcium; Magnesium; PC(32:0); PS(16:0/16:0); PA(16:0/16:0); Acetylcholine; NAD; FADH; FAD; Manganese; Palmityl-CoA; Citicoline; Dihydroxyacetone phosphate; NADH; Phosphorylcholine; CDP-DG(16:0/16:0); DG(16:0/16:0); LysoPA(16:0/0:0); PE(16:0/16:0); PI(16:0/16:0); LysoPC(16:0/0:0); PG(16:0/16:0); LysoPE(16:0/0:0); PGP(16:0/16:0); CL(16:0/16:0/16:0/16:0)

Bile acid biosynthesis

65

2

0.324

0.0365

1

1

Chenodeoxycholic acid glycine conjugate; Taurochenodesoxycholic acid

Taurocholic acid; Cholesterol; Glycine; Glycocholic acid; NADP; Palmitic acid; NADPH; Pyrophosphate; Taurine; 3alpha,7alpha-Dihydroxycoprostanic acid; Chenodeoxycholic acid; Adenosine triphosphate; Cholic acid; Deoxycholic acid; Deoxycholic acid glycine conjugate; Chenodeoxycholic acid glycine conjugate; Lithocholic acid glycine conjugate; Lithocholyltaurine; Lithocholic acid; Taurodeoxycholic acid; NAD; Taurochenodesoxycholic acid; 27-Deoxy-5b-cyprinol; FAD; Propionyl-CoA; ADP; Choloyl-CoA; Oxygen; 24-Hydroxycholesterol; Coenzyme A; 5beta-Cholestane-3alpha,7alpha,12alpha-triol; NADH; 7alpha-Hydroxycholesterol; 7a-Hydroxy-cholestene-3-one; 27-Hydroxycholesterol; Water; 3a,7a-Dihydroxy-5b-cholestanoyl-CoA; 7a,12a-Dihydroxy-cholestene-3-one; Heme; 3a,7a,12a-Trihydroxy-5b-cholestan-26-al; 3'-AMP; Coprocholic acid; 25-Hydroxycholesterol; 7-a,25-Dihydroxycholesterol; 7-a,27-Dihydroxycholesterol; Chenodeoxycholoyl-CoA; CE(22:2); 7a,12a-Dihydroxy-5b-cholestan-3-one; 5b-Cyprinol sulfate; 3a,7a,12a-Trihydroxy-5b-cholest-24-enoyl-CoA; 3a,7a,12a,24-Tetrahydroxy-5b-cholestanoyl-CoA; 3a,7a,12a-Trihydroxy-5b-24-oxocholestanoyl-CoA; 7a-Hydroxy-5b-cholestan-3-one; 3a,7a-Dihydroxy-5b-cholestane; 3a,7a-Dihydroxy-5b-cholestan-26-al; 3a,7a-Dihydroxy-5b-cholest-24-enoyl-CoA; (24R)-Cholest-5-ene-3-beta,7-alpha,24-triol; 3beta-Hydroxy-5-cholestenoic acid; 3beta,7alpha-Dihydroxy-5-cholestenoate; 3 alpha,7 alpha,26-Trihydroxy-5beta-cholestane; 3 alpha,7 alpha,24-Trihydroxy-5beta-cholestanoyl-CoA; 7 alpha,24-Dihydroxy-4-cholesten-3-one; 7alpha-Hydroxy-3-oxo-4-cholestenoate; 7 alpha,26-Dihydroxy-4-cholesten-3-one; Iron

Androgen and estrogen metabolism

33

1

0.165

0.154

1

1

Dehydroepiandrosterone sulfate;

Androstenedione; Adenosine 3',5'-diphosphate; Dehydroepiandrosterone; Formic acid; Estrone; Estradiol; NADP; NADPH; Testosterone; Uridine 5'-diphosphate; 17a-Hydroxypregnenolone; 17-Hydroxyprogesterone; Calcium; NAD; Uridine diphosphate glucuronic acid; Dehydroepiandrosterone sulfate; Phosphoadenosine phosphosulfate; Oxygen; Estrone sulfate; Sulfate; NADH; Water; Androsterone sulfate; Dihydrotestosterone; Heme; Testosterone glucuronide; 19-Hydroxyandrost-4-ene-3,17-dione; 19-Oxotestosterone; 17-beta-Estradiol-3-glucuronide; 19-Oxoandrost-4-ene-3,17-dione; 19-Hydroxytestosterone; 5b-Dihydrotestosterone; Hydrogen Ion

  1. “Hits” refers to the data points identified in data analysis that conform to specific standards or models; “Expect” refers to the expected value used to evaluate the quality of random matches; “Holm P” refers to the p-value adjusted by the Holm-Bonferroni method
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Lipids in Health and Disease

ISSN: 1476-511X