Skip to main content
Scheme 1 | Lipids in Health and Disease

Scheme 1

From: Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma

Scheme 1

Diagnosis strategies for metabolic reprogramming in human primary HCC and CCA. This study utilized UPLC‒Q-TOF/MS to conduct a thorough, non-targeted metabolomics analysis, identifying a notable upregulation of lipid metabolites, including PC and LysoPC, in patients with HCC and CCA, which were particularly enriched in the GPL metabolic pathway. H&E and IHC staining revealed a significant increase in PLA2 expression in tumor tissues, underscoring the crucial role of lipid metabolism in cancer progression and its potential as a therapeutic target. These findings offer fresh insights into the clinical challenges of HCC and CCA, supporting the advancement of early diagnostic and personalized treatment strategies to deliver customized and precise therapeutic options for patients

Back to article page

Lipids in Health and Disease

ISSN: 1476-511X