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Fig. 3 | Lipids in Health and Disease

Fig. 3

From: Glycerophospholipid-driven lipid metabolic reprogramming as a common key mechanism in the progression of human primary hepatocellular carcinoma and cholangiocarcinoma

Fig. 3

Interaction analysis of untargeted LC‒MS metabolomics in primary liver cancer and cholangiocarcinoma. A Volcano plot of the HCC and CCA groups. B Hierarchical clustering analysis of HCC and CCA samples. C Unsupervised PCA score plots of metabolomic phenotypes between the HCC and CCA groups. Model parameter: R2X = 0.853 (cumulative variance proportion of 2 principal components). D Score plot of the OPLS-DA model to maximize the intergroup differentiation of the metabolomic data between the HCC and CCA groups. E Model parameters: 1 predictive component + 1 orthogonal component, R2Y = 0.697, and Q2 = 0.38. OPLS-DA permutation test diagram of the HCC and CCA groups. F ROC plot of the OPLS-DA model differentiating the HCC and CCA groups. G Hierarchical clustering heatmap of differentially abundant metabolites between the HCC and CCA groups. H Correlation heatmaps of differentially abundant metabolites between the HCC and CCA groups. I KEGG pathway enrichment diagram for the HCC and CCA groups

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Lipids in Health and Disease

ISSN: 1476-511X